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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1992-8-14
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pubmed:abstractText |
In a primary immune response a signal from interleukin 2 (IL-2) induces B lymphocytes to express the gene for the IgM joining component, the J chain. The signaling mechanism was pursued in this study by examining the J-chain gene 5' flanking region for regulatory sequences and interacting nuclear factors. The analyses identified a major control region located between -75 and -45 that encodes two adjacent elements: a T-rich sequence (JA) containing a single positive regulatory motif and an A+G-rich sequence (JB) containing overlapping positive and negative regulatory motifs. Dissection of the two elements indicated that the bifunctional JB sequence is the likely target of the IL-2 signal. The evidence was based on findings that (i) JB activity correlated with J-chain gene transcription--i.e., JB acts as a repressor in J-chain-silent B cells and as an activator in J-chain-expressing cells, and (ii) JB activator function is mediated by a B-cell-specific nuclear protein, NF-JB, that exhibits an IL-2-responsive binding pattern.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-1690713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-1763018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-1824727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-2106566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-2147515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-2253872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-2492678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-2495329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-2497989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-2688708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3025626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3025641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3096574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3259228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3260003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3322397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3881765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-3924411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6092511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6409417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6427923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6439814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6439815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6781757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6960240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631082-6975347
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5966-70
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1631082-Animals,
pubmed-meshheading:1631082-B-Lymphocytes,
pubmed-meshheading:1631082-Base Sequence,
pubmed-meshheading:1631082-DNA-Binding Proteins,
pubmed-meshheading:1631082-Gene Expression Regulation,
pubmed-meshheading:1631082-Genes, Immunoglobulin,
pubmed-meshheading:1631082-Immunoglobulin J-Chains,
pubmed-meshheading:1631082-Interleukin-2,
pubmed-meshheading:1631082-Mice,
pubmed-meshheading:1631082-Molecular Sequence Data,
pubmed-meshheading:1631082-Mutagenesis, Site-Directed,
pubmed-meshheading:1631082-Nuclear Proteins,
pubmed-meshheading:1631082-Promoter Regions, Genetic,
pubmed-meshheading:1631082-Regulatory Sequences, Nucleic Acid
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pubmed:year |
1992
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pubmed:articleTitle |
A promoter element that exerts positive and negative control of the interleukin 2-responsive J-chain gene.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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