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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1992-8-14
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pubmed:abstractText |
We report that visual stimulation produces an easily detectable (5-20%) transient increase in the intensity of water proton magnetic resonance signals in human primary visual cortex in gradient echo images at 4-T magnetic-field strength. The observed changes predominantly occur in areas containing gray matter and can be used to produce high-spatial-resolution functional brain maps in humans. Reducing the image-acquisition echo time from 40 msec to 8 msec reduces the amplitude of the fractional signal change, suggesting that it is produced by a change in apparent transverse relaxation time T*2. The amplitude, sign, and echo-time dependence of these intrinsic signal changes are consistent with the idea that neural activation increases regional cerebral blood flow and concomitantly increases venous-blood oxygenation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-1775048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-1798390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-1925560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-1948051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-2062208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-2117272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-2124706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-2161986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-2255240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-2355830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-3260686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-3485282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-3696078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1631079-6275909
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5951-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1992
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pubmed:articleTitle |
Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.
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pubmed:affiliation |
Biological Computation Research Department, AT&T Bell Laboratories, Murray Hill, NJ 07974.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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