Hyperhomocysteinemia is commonly associated with polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene. The level of homocysteine can be lowered by dietary intake of folate. A protective effect of folate supplementation has been reported against cataract. Here we investigate MTHFR polymorphisms in human cataract.
Institute of Clinical Neuroscience, Section of Ophthalmology, Sahlgrenska University Hospital, Göteborg University, Mölndal, Sweden. madeleine.zetterberg@anatcell.gu.se