Linked Life Data

1631027

Source:http://linkedlifedata.com/resource/pubmed/id/1631027

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-8-20
pubmed:abstractText
Biochemical composition and variables of protein turnover were determined in rat placenta at 21 days gestation in control animals and in animals subjected to 72-h fasting and protein/calorie restriction (6 per cent protein) throughout gestation. Placental protein synthesis was determined following the injection of 'massive' amounts of 14C-phenylalanine intravenously to the pregnant rat. Protein content was reduced in placentas from rats that were fasted for 72 h and in those who were protein restricted throughout pregnancy. Placental RNA content was significantly reduced only in the protein-restricted animals. Fractional rates of protein synthesis were reduced in placentas from the protein-restricted animals (Ks = 17.9 +/- 0.8 per cent per day in controls versus 11.7 +/- 0.9 in protein restricted, P = 0.002), but not in fasted animals. Fractional protein breakdown was markedly enhanced in placentas following maternal fasting (Kd = 9.9 per cent per day in controls versus 26.0 per cent in fasted), but not affected by protein deprivation. These results mimic those previously reported for other fetal tissues under these experimental conditions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0143-4004
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-50
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Protein turnover in rat placenta: effects of maternal fasting and maternal protein restriction.
pubmed:affiliation
Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque 87131.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.