Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2005-11-24
pubmed:abstractText
Human immunodeficiency virus type 1 (HIV-1) evolves in vivo under selective pressure from CD8+ T-lymphocyte (CTL) responses, which are in turn determined by host and viral genetic factors, such as restricting major histocompatibility complex molecules and the available viral epitope sequences. However, CTL are derived stochastically through the random gene rearrangements to produce T-cell receptors (TCR), and the relative impact of genetic versus stochastic processes on CTL targeting of HIV and immune-driven viral evolution is unclear. Here we evaluate identical twins infected with HIV-1 as neonates from a common blood transfusion, with subsequently similar environmental exposures, thereby allowing controlled comparisons of CTL targeting and viral evolution. Seventeen years after infection, their CTL targeting of HIV-1 was remarkably similar. In contrast, their overall TCR profiles were highly dissimilar, and a dominant epitope was recognized by distinctly different TCR in each twin. Furthermore, their viral epitopes had diverged, and there was ongoing viral phylogenetic divergence between the twins between 12 and 17 years after infection. These results indicate that while CTL targeting is predominately genetically determined, stochastic influences render the interaction of HIV-1 and host immunity, and therefore viral escape and CTL efficacy, unpredictable.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-10075982, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-10869039, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-10982361, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-11238990, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-11413294, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-11797012, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-11884484, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-11958684, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12029127, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12093686, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12134267, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12396457, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12459786, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12547502, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12626462, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-12743169, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-14530132, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-15036041, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-15452249, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-3496541, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-7494338, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-7529365, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-7541846, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-7816094, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-7824947, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-8057491, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-8207839, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-8235655, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-9060675, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-9084787, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-9143689, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-9420212, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-9451962, http://linkedlifedata.com/resource/pubmed/commentcorrection/16306608-9933172
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15368-75
pubmed:dateRevised
2011-4-22
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Genetic and stochastic influences on the interaction of human immunodeficiency virus type 1 and cytotoxic T lymphocytes in identical twins.
pubmed:affiliation
UCLA AIDS Institute and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA. oyang@mednet.ucla.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural, Twin Study