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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
49
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pubmed:dateCreated |
2005-12-7
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pubmed:abstractText |
Mathematical modeling was performed to test the extent to which cytopathic and noncytopathic T cell effector functions contribute to resolution of hepatitis B virus (HBV) infection in three acutely infected chimpanzees. Simulations based exclusively on cytopathic functions show a poor fit to the data and would require the destruction and regeneration of approximately 11 livers for clearance to occur. In contrast, a simulation based on a combination of cytopathic and noncytopathic functions provided a significantly better fit to the data (P < 0.001) and required as much as 5-fold less destruction to clear the virus from the liver. The best fit simulation supports the notion that during the early phase of HBV clearance, noncytopathic T cell effector mechanisms inhibit viral replication and greatly shorten the half-life of the long lived covalently closed circular viral DNA transcriptional template, thereby limiting the extent to which cytopathic T cell effector functions and tissue destruction are required to terminate acute HBV infection.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-10221919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-10627561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-10717294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-10799602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-11119601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-12477811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-14500915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-14764900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-15657132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-1660137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-1711541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-1738197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-6180831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-7532675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-7612225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-7666518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-7679709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-7683326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-7914548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-7966625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-8170985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-8574849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16306261-8855174
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17780-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2005
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pubmed:articleTitle |
Dynamics of hepatitis B virus clearance in chimpanzees.
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pubmed:affiliation |
School of Mathematics, University of New South Wales, Sydney NSW 2052, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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