16305605

Source:http://linkedlifedata.com/resource/pubmed/id/16305605

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0034735, umls-concept:C0035309, umls-concept:C0035647, umls-concept:C0149931, umls-concept:C0439660, umls-concept:C0442805, umls-concept:C1708726, umls-concept:C1801960
pubmed:issue	12
pubmed:dateCreated	2005-11-24
pubmed:abstractText	Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8200710
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0333-1024
pubmed:author	pubmed-author:FerraroM JMJ, pubmed-author:FrantsR RRR, pubmed-author:HabaTT, pubmed-author:HottengaJ JJJ, pubmed-author:Kheradmand KiaSS, pubmed-author:KornE JEJ, pubmed-author:TerwindtG MGM, pubmed-author:VanmolkotK R JKR, pubmed-author:de JongP T V MPT, pubmed-author:van den MaagdenbergA M J MAM
pubmed:issnType	Print
pubmed:volume	25
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1168-72
pubmed:dateRevised	2008-2-11
pubmed:meshHeading	pubmed-meshheading:16305605-Adolescent, pubmed-meshheading:16305605-Adult, pubmed-meshheading:16305605-Child, pubmed-meshheading:16305605-Comorbidity, pubmed-meshheading:16305605-Female, pubmed-meshheading:16305605-Genes, Dominant, pubmed-meshheading:16305605-Genetic Predisposition to Disease, pubmed-meshheading:16305605-Haplotypes, pubmed-meshheading:16305605-Humans, pubmed-meshheading:16305605-Male, pubmed-meshheading:16305605-Migraine Disorders, pubmed-meshheading:16305605-Netherlands, pubmed-meshheading:16305605-Phenotype, pubmed-meshheading:16305605-Prevalence, pubmed-meshheading:16305605-Quantitative Trait, Heritable, pubmed-meshheading:16305605-Quantitative Trait Loci, pubmed-meshheading:16305605-Raynaud Disease, pubmed-meshheading:16305605-Retinal Diseases, pubmed-meshheading:16305605-Risk Assessment, pubmed-meshheading:16305605-Sequence Analysis, DNA
pubmed:year	2005
pubmed:articleTitle	The 3p21.1-p21.3 hereditary vascular retinopathy locus increases the risk for Raynaud's phenomenon and migraine.
pubmed:affiliation	Department of Human Genetics, Leiden University Medical Centre, Leiden, and Department of Neurology, Rijnland Hospital, Leiderdorp, The Netherlands.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Clinical Trial, Phase I