Source:http://linkedlifedata.com/resource/pubmed/id/16302230
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2005-11-30
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pubmed:abstractText |
In the present study, we established transgenic mice overexpressing Del1, a ligand of integrins, to examine the effect of overexpression of Del1 on vascular morphogenesis. In the wild-type mouse, mesenteric vessels are shaped like rakes consisting of a long stalk and short branches at the periphery. In contrast, those in transgenic mice showed typical dendritic architecture consisting of a few large primary branches with smaller spreading branches. The phenotype of mice overexpressing Del1 suggests the existence of a tissue-specific mechanism for branching morphogenesis in the mesentery.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1552-4884
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2005 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
287
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1165-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16302230-Animals,
pubmed-meshheading:16302230-Carrier Proteins,
pubmed-meshheading:16302230-Cell Culture Techniques,
pubmed-meshheading:16302230-Gene Expression Regulation, Developmental,
pubmed-meshheading:16302230-Immunohistochemistry,
pubmed-meshheading:16302230-In Situ Hybridization,
pubmed-meshheading:16302230-Mesentery,
pubmed-meshheading:16302230-Mice,
pubmed-meshheading:16302230-Mice, Transgenic,
pubmed-meshheading:16302230-Microscopy, Electron,
pubmed-meshheading:16302230-Morphogenesis,
pubmed-meshheading:16302230-Neovascularization, Physiologic,
pubmed-meshheading:16302230-Phenotype
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pubmed:year |
2005
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pubmed:articleTitle |
Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery.
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pubmed:affiliation |
Research Center for Advanced Medicine, Nihon University School of Medicine, and Aoyama Hospital, Tokyo, Japan. hidai@med.nihon-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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