|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0027126,
umls-concept:C0030664,
umls-concept:C0752354,
umls-concept:C1300562,
umls-concept:C1414081,
umls-concept:C1414085,
umls-concept:C1415938,
umls-concept:C1415941,
umls-concept:C1720655,
umls-concept:C1947974,
umls-concept:C2348205,
umls-concept:C2700455,
umls-concept:C2931688,
umls-concept:C2931689
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|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2005-11-22
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|
pubmed:abstractText |
Neurofibrillary degeneration (NFD) occurs in the brains of patients with myotonic dystrophy (DM) type 1. The authors report a similar tau pathology in the CNS of a patient with DM2 and compare it to that of patients with DM1. A reduced expression of tau exon 2 and exon 3 epitopes is observed in both DM1 and DM2. This suggests a similar physiopathologic process that may contribute to common neurologic features in patients with DM.
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pubmed:language |
eng
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|
pubmed:journal |
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|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1526-632X
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
65
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1636-8
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pubmed:dateRevised |
2008-5-13
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pubmed:meshHeading |
pubmed-meshheading:16301494-Aged,
pubmed-meshheading:16301494-Antibody Specificity,
pubmed-meshheading:16301494-Brain,
pubmed-meshheading:16301494-DNA Mutational Analysis,
pubmed-meshheading:16301494-Epitopes,
pubmed-meshheading:16301494-Exons,
pubmed-meshheading:16301494-Female,
pubmed-meshheading:16301494-Genetic Predisposition to Disease,
pubmed-meshheading:16301494-Hippocampus,
pubmed-meshheading:16301494-Humans,
pubmed-meshheading:16301494-Immunohistochemistry,
pubmed-meshheading:16301494-Inclusion Bodies,
pubmed-meshheading:16301494-Male,
pubmed-meshheading:16301494-Middle Aged,
pubmed-meshheading:16301494-Mutation,
pubmed-meshheading:16301494-Myotonic Dystrophy,
pubmed-meshheading:16301494-Neurofibrillary Tangles,
pubmed-meshheading:16301494-Neurons,
pubmed-meshheading:16301494-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16301494-RNA-Binding Proteins,
pubmed-meshheading:16301494-Tauopathies,
pubmed-meshheading:16301494-tau Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Similar brain tau pathology in DM2/PROMM and DM1/Steinert disease.
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|
pubmed:affiliation |
INSERM U422, Faculté de Médecine, Lille, France. ca-maurage@chru-lille.fr
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
