Source:http://linkedlifedata.com/resource/pubmed/id/16300945
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2006-1-9
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| pubmed:abstractText |
Aplysamine-1 (1), a marine natural product, was synthesized and screened for in vitro activity at the human and rat histamine H3 receptors. Aplysamine-1 (1) was found to possess a high binding affinity for the human H3 receptor (Ki = 30+/-4 nM). Synthetic analogs of 1, including des-bromoaplysamine-1 (10) and dimethyl-{2-[4-(3-piperidin-1-yl-propoxy)-phenyl]-ethyl}-amine (13), were potent H3 antagonists.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
897-900
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| pubmed:meshHeading |
pubmed-meshheading:16300945-Animals,
pubmed-meshheading:16300945-Drug Evaluation, Preclinical,
pubmed-meshheading:16300945-Humans,
pubmed-meshheading:16300945-Ligands,
pubmed-meshheading:16300945-Molecular Structure,
pubmed-meshheading:16300945-Rats,
pubmed-meshheading:16300945-Receptors, Histamine H3,
pubmed-meshheading:16300945-Structure-Activity Relationship,
pubmed-meshheading:16300945-Tyrosine
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Aplysamine-1 and related analogs as histamine H3 receptor antagonists.
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| pubmed:affiliation |
Johnson & Johnson Pharmaceutical Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. dswanso1@prdus.jnj.com
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| pubmed:publicationType |
Journal Article
|