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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2005-11-21
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pubmed:abstractText |
Preoperative thrombocytosis (platelet count > 400 x 10(9)/L) at initial exploration for epithelial ovarian carcinoma is associated with decreased surgical cytoreducibility and poor survival. Platelets express androgen receptor (AR), which contains a polymorphic CAG trinucleotide repeat sequence of which the length inversely correlates with AR transactivation function. We hypothesized that androgen-mediated thrombocytosis promotes aggressive ovarian cancer biology.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8015-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16299230-Alleles,
pubmed-meshheading:16299230-Androgens,
pubmed-meshheading:16299230-Epithelial Cells,
pubmed-meshheading:16299230-Female,
pubmed-meshheading:16299230-Gene Frequency,
pubmed-meshheading:16299230-Genotype,
pubmed-meshheading:16299230-Humans,
pubmed-meshheading:16299230-Logistic Models,
pubmed-meshheading:16299230-Middle Aged,
pubmed-meshheading:16299230-Multivariate Analysis,
pubmed-meshheading:16299230-Ovarian Neoplasms,
pubmed-meshheading:16299230-Prognosis,
pubmed-meshheading:16299230-Receptors, Androgen,
pubmed-meshheading:16299230-Survival Analysis,
pubmed-meshheading:16299230-Thrombocytosis,
pubmed-meshheading:16299230-Trinucleotide Repeats
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pubmed:year |
2005
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pubmed:articleTitle |
Androgen mediation of thrombocytosis in epithelial ovarian cancer biology.
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pubmed:affiliation |
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. Andrew.Li@cshs.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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