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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-2-1
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pubmed:abstractText |
Permeabilized rat soleus muscle fibers were subjected to rapid shortening/restretch protocols (20% muscle length, 20 ms duration) in solutions with pCa values ranging from 6.5 to 4.5. Force redeveloped after each restretch but temporarily exceeded the steady-state isometric tension reaching a maximum value approximately 2.5 s after relengthening. The relative size of the overshoot was <5% in pCa 6.5 and pCa 4.5 solutions but equaled 17% +/- 4% at pCa 6.0 (approximately half-maximal Ca2+ activation). Muscle stiffness was estimated during pCa 6.0 activations by imposing length steps at different time intervals after repeated shortening/restretch perturbations. Relative stiffness and relative tension were correlated (p < 0.001) during recovery, suggesting that tension overshoots reflect a temporary increase in the number of attached cross-bridges. Rates of tension recovery (k(tr)) correlated (p < 0.001) with the relative residual force prevailing immediately after restretch. Force also recovered to the isometric value more quickly at 5.7 < or = pCa < or = 5.9 than at pCa 4.5 (ANOVA, p < 0.05). These results show that k(tr) measurements underestimate the rate of isometric force development during submaximal Ca2+ activations and suggest that the rate of tension recovery is limited primarily by the availability of actin binding sites.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16299074-10747208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16299074-11222304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16299074-11701614,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-3495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1288-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16299074-Animals,
pubmed-meshheading:16299074-Calcium,
pubmed-meshheading:16299074-Female,
pubmed-meshheading:16299074-Isometric Contraction,
pubmed-meshheading:16299074-Muscle, Skeletal,
pubmed-meshheading:16299074-Muscle Contraction,
pubmed-meshheading:16299074-Muscle Fibers, Skeletal,
pubmed-meshheading:16299074-Muscle Relaxation,
pubmed-meshheading:16299074-Permeability,
pubmed-meshheading:16299074-Rats,
pubmed-meshheading:16299074-Rats, Sprague-Dawley,
pubmed-meshheading:16299074-Sarcomeres
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pubmed:year |
2006
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pubmed:articleTitle |
Tension recovery in permeabilized rat soleus muscle fibers after rapid shortening and restretch.
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pubmed:affiliation |
Department of Physiology, University of Kentucky, Lexington, Kentucky, USA. k.s.campbell@uky.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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