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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-12
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pubmed:abstractText |
The small GTPase of Ras and Rho families are widely involved in human tumorgenesis and metastasis. It has recently been reported that pamidronate inhibits the mevalonate pathway, which is required for the prenylation of the small GTPase. We demonstrated a possible beneficial use of pamidronate in the treatment of hepatocellular carcinoma (HCC).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
142-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16298452-Animals,
pubmed-meshheading:16298452-Antineoplastic Agents,
pubmed-meshheading:16298452-Apoptosis,
pubmed-meshheading:16298452-Carcinoma, Hepatocellular,
pubmed-meshheading:16298452-Cell Line, Tumor,
pubmed-meshheading:16298452-Cell Movement,
pubmed-meshheading:16298452-Cell Proliferation,
pubmed-meshheading:16298452-Diphosphonates,
pubmed-meshheading:16298452-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16298452-Female,
pubmed-meshheading:16298452-Humans,
pubmed-meshheading:16298452-Immunoblotting,
pubmed-meshheading:16298452-In Situ Nick-End Labeling,
pubmed-meshheading:16298452-Liver Neoplasms,
pubmed-meshheading:16298452-Mice,
pubmed-meshheading:16298452-Mice, Inbred BALB C
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pubmed:year |
2006
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pubmed:articleTitle |
Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma.
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pubmed:affiliation |
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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