Source:http://linkedlifedata.com/resource/pubmed/id/16298371
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0021655,
umls-concept:C0032659,
umls-concept:C0052191,
umls-concept:C0205217,
umls-concept:C0242339,
umls-concept:C0332281,
umls-concept:C0441889,
umls-concept:C0580545,
umls-concept:C0681850,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1880177,
umls-concept:C2349001,
umls-concept:C2697811
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| pubmed:issue |
1
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| pubmed:dateCreated |
2006-8-7
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| pubmed:abstractText |
Despite the major role of insulin in regulating apolipoprotein C-III (apo C-III) production, little is known about the relationship between apo C-III and insulin resistance. We examined this relationship, and the association of apo C-III with dyslipidemia, in a triethnic sample of 168 subjects with normoglycemia or type 2 diabetes. African-Americans had lower triglycerides (1.21 +/- 0.11 mmol/l) compared with Hispanics (2.01 +/- 0.14 mmol/l) and white non-Hispanics (1.83 +/- 0.15 mmol/l), regardless of gender and type 2 diabetes status (P < 0.01), but this difference was partially accounted for by ethnic difference in apo C-III levels. Metabolic syndrome was associated with high apo C-III (> 14 mg/dl) in Hispanics (OR = 5.6; 95%CI: 1.3-23.4) and white non-Hispanics (OR = 6.9; 95%CI: 1.3-36.4), but not in African-Americans. Apo C-III was the best predictor of triglycerides (R2 = 0.54, P < 0.001), after accounting for demographic and clinical variables. We found an inverse relationship between apo C-III levels and low-density lipoprotein (LDL) particle size in the type 2 diabetes subjects with (r = -0.36, P = 0.02) and without (r = -0.47, P = 0.02) the metabolic syndrome, but in normoglycemic subjects an inverse relationship was evident only in metabolic syndrome subjects (r = -0.52, P < 0.01). These results suggest that higher apo C-III may contribute to the increased cardiovascular risk in subjects with insulin resistance and type 2 diabetes through its effects on triglycerides and LDL particle size.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0021-9150
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
188
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
134-41
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:16298371-Adult,
pubmed-meshheading:16298371-Aged,
pubmed-meshheading:16298371-Apolipoprotein C-III,
pubmed-meshheading:16298371-Cardiovascular Diseases,
pubmed-meshheading:16298371-Diabetes Mellitus, Type 2,
pubmed-meshheading:16298371-Dyslipidemias,
pubmed-meshheading:16298371-Ethnic Groups,
pubmed-meshheading:16298371-Female,
pubmed-meshheading:16298371-Humans,
pubmed-meshheading:16298371-Hypertriglyceridemia,
pubmed-meshheading:16298371-Insulin Resistance,
pubmed-meshheading:16298371-Lipoproteins, LDL,
pubmed-meshheading:16298371-Male,
pubmed-meshheading:16298371-Metabolic Syndrome X,
pubmed-meshheading:16298371-Middle Aged,
pubmed-meshheading:16298371-Particle Size,
pubmed-meshheading:16298371-Risk Factors,
pubmed-meshheading:16298371-Triglycerides
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| pubmed:year |
2006
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| pubmed:articleTitle |
Increased apolipoprotein C-III levels associated with insulin resistance contribute to dyslipidemia in normoglycemic and diabetic subjects from a triethnic population.
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| pubmed:affiliation |
University of Miami Miller School of Medicine, Miami, FL, USA. hflorez@med.miami.edu
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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