Source:http://linkedlifedata.com/resource/pubmed/id/16298129
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2006-1-9
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| pubmed:abstractText |
The preparation and biological evaluation of 5-substituted-6-hydroxy-2-(anilino)pyrimidinones as a new class of DNA polymerase IIIC inhibitors, required for the replication of chromosomal DNA in Gram-positive bacteria, are described. These new dGTP competitive inhibitors displayed good levels of in vitro inhibition and antibacterial activity against Staphylococcus aureus. A new class of dATP competitive inhibitors, 6-substituted-2-amino-5-alkyl-pyrimidin-4-ones, whose antibacterial activity was unaffected by serum, were identified.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
891-6
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| pubmed:meshHeading |
pubmed-meshheading:16298129-DNA Polymerase III,
pubmed-meshheading:16298129-Dose-Response Relationship, Drug,
pubmed-meshheading:16298129-Enzyme Inhibitors,
pubmed-meshheading:16298129-Microbial Sensitivity Tests,
pubmed-meshheading:16298129-Molecular Structure,
pubmed-meshheading:16298129-Pyrimidinones,
pubmed-meshheading:16298129-Staphylococcus aureus,
pubmed-meshheading:16298129-Structure-Activity Relationship
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC.
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| pubmed:affiliation |
Targanta Therapeutics Inc., 7170 Frederick-Banting, 2nd Floor, Montréal, Québec, Canada H4S 2A1. yrose@targanta.com
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| pubmed:publicationType |
Journal Article
|