| pubmed-article:16297587 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16297587 | lifeskim:mentions | umls-concept:C0035648 | lld:lifeskim |
| pubmed-article:16297587 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:16297587 | lifeskim:mentions | umls-concept:C1704829 | lld:lifeskim |
| pubmed-article:16297587 | lifeskim:mentions | umls-concept:C0678951 | lld:lifeskim |
| pubmed-article:16297587 | lifeskim:mentions | umls-concept:C0033522 | lld:lifeskim |
| pubmed-article:16297587 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16297587 | pubmed:dateCreated | 2006-1-9 | lld:pubmed |
| pubmed-article:16297587 | pubmed:abstractText | Risk of incident dementia from any cause and Alzheimer's disease (AD) in relation to the IL-1beta-511 (C-->T) and IL-6-174 (G-->C) polymorphisms was investigated in an Italian elderly cohort (n=791) with 4 years of follow-up. Analyses were adjusted for socio-demographic confounders (age, gender, education), presence of the Apolipoprotein E-epsilon4 allele, and plasma total homocysteine (tHcy), a newly proposed AD risk factor. No significant association was found for the IL-1beta-511 and IL-6-174 polymorphisms with either dementia or AD. However, in the baseline dementia-free cohort considered as a whole, independently of other confounders, IL-1beta-511 T/T homozygotes had lower plasma tHcy than both heterozygotes (P=0.036) and wild-types (P=0.004). These data do not support the hypothesis that the IL-1-beta-511 and IL-6-174 polymorphisms affect dementia or AD risk. The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD. | lld:pubmed |
| pubmed-article:16297587 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16297587 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297587 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16297587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16297587 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16297587 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16297587 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16297587 | pubmed:issn | 0531-5565 | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:RavagliaGiova... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:FortiPaolaP | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:MaioliFabiola... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:BolondiLuigiL | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:LicastroFeder... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:ChiappelliMar... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:MartelliMabel... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:BastagliLucia... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:BianchinMaris... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:MontesiFausta... | lld:pubmed |
| pubmed-article:16297587 | pubmed:author | pubmed-author:TuminiEmanuel... | lld:pubmed |
| pubmed-article:16297587 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16297587 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:16297587 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16297587 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16297587 | pubmed:pagination | 85-92 | lld:pubmed |
| pubmed-article:16297587 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16297587 | pubmed:meshHeading | pubmed-meshheading:16297587... | lld:pubmed |
| pubmed-article:16297587 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16297587 | pubmed:articleTitle | Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study. | lld:pubmed |
| pubmed-article:16297587 | pubmed:affiliation | Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti, 9-40138 Bologna, Italy. ravaglia@med.unibo.it | lld:pubmed |
| pubmed-article:16297587 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16297587 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16297587 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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