rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-9
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pubmed:abstractText |
Risk of incident dementia from any cause and Alzheimer's disease (AD) in relation to the IL-1beta-511 (C-->T) and IL-6-174 (G-->C) polymorphisms was investigated in an Italian elderly cohort (n=791) with 4 years of follow-up. Analyses were adjusted for socio-demographic confounders (age, gender, education), presence of the Apolipoprotein E-epsilon4 allele, and plasma total homocysteine (tHcy), a newly proposed AD risk factor. No significant association was found for the IL-1beta-511 and IL-6-174 polymorphisms with either dementia or AD. However, in the baseline dementia-free cohort considered as a whole, independently of other confounders, IL-1beta-511 T/T homozygotes had lower plasma tHcy than both heterozygotes (P=0.036) and wild-types (P=0.004). These data do not support the hypothesis that the IL-1-beta-511 and IL-6-174 polymorphisms affect dementia or AD risk. The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
pubmed:issn |
0531-5565
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pubmed:author |
pubmed-author:BastagliLucianaL,
pubmed-author:BianchinMarisaM,
pubmed-author:BolondiLuigiL,
pubmed-author:ChiappelliMartinaM,
pubmed-author:FortiPaolaP,
pubmed-author:LicastroFedericoF,
pubmed-author:MaioliFabiolaF,
pubmed-author:MartelliMabelM,
pubmed-author:MontesiFaustaF,
pubmed-author:RavagliaGiovanniG,
pubmed-author:TuminiEmanuelaE
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pubmed:issnType |
Print
|
pubmed:volume |
41
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
85-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16297587-Aged,
pubmed-meshheading:16297587-Aged, 80 and over,
pubmed-meshheading:16297587-Alleles,
pubmed-meshheading:16297587-Alzheimer Disease,
pubmed-meshheading:16297587-Apolipoprotein E4,
pubmed-meshheading:16297587-Apolipoproteins E,
pubmed-meshheading:16297587-Dementia,
pubmed-meshheading:16297587-Female,
pubmed-meshheading:16297587-Genetic Predisposition to Disease,
pubmed-meshheading:16297587-Homocysteine,
pubmed-meshheading:16297587-Humans,
pubmed-meshheading:16297587-Interleukin-1,
pubmed-meshheading:16297587-Interleukin-6,
pubmed-meshheading:16297587-Male,
pubmed-meshheading:16297587-Polymorphism, Genetic,
pubmed-meshheading:16297587-Prospective Studies,
pubmed-meshheading:16297587-Risk Factors
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pubmed:year |
2006
|
pubmed:articleTitle |
Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study.
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pubmed:affiliation |
Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti, 9-40138 Bologna, Italy. ravaglia@med.unibo.it
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|