Source:http://linkedlifedata.com/resource/pubmed/id/16296710
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2005-11-21
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| pubmed:abstractText |
This study was a multicenter, double-blind comparison of the antianginal efficacy and safety of amlodipine and placebo as adjunctive therapy with constant recommended maintenance doses of beta-blockers. Patients with stable exertional angina pectoris were randomized to placebo or amlodipine at a starting dose of 5 mg once daily. The amlodipine dose was adjusted to 10 mg daily after 2 weeks if angina attacks were not abolished. Antianginal efficacy was assessed throughout the study with angina diaries, investigators' and patients' global evaluations, and with bicycle exercise tests during a placebo run-in period (baseline) and after 2 and 6 weeks of double-blind treatment. On baseline-final analysis, the exercise time to angina onset increased by 13% with amlodipine compared to 6% with placebo (p < 0.05). The total exercise time increased by 11% on amlodipine compared with 2% on placebo, though this difference did not reach statistical significance. Angina attack frequency and nitroglycerin consumption were both reduced by adding amlodipine to beta-blocker treatment. Amlodipine in combination with beta-blocker therapy was well tolerated, with a low incidence of side effects and laboratory test abnormalities. The study showed clearly that addition of amlodipine to beta-blocker therapy in patients with stable angina pectoris was well tolerated and gave improved antianginal efficacy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Amlodipine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroglycerin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0160-2446
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
17 Suppl 1
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S50-2
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16296710-Adolescent,
pubmed-meshheading:16296710-Adrenergic beta-Antagonists,
pubmed-meshheading:16296710-Adult,
pubmed-meshheading:16296710-Aged,
pubmed-meshheading:16296710-Amlodipine,
pubmed-meshheading:16296710-Angina Pectoris,
pubmed-meshheading:16296710-Calcium Channel Blockers,
pubmed-meshheading:16296710-Double-Blind Method,
pubmed-meshheading:16296710-Drug Therapy, Combination,
pubmed-meshheading:16296710-Exercise Test,
pubmed-meshheading:16296710-Female,
pubmed-meshheading:16296710-Humans,
pubmed-meshheading:16296710-Male,
pubmed-meshheading:16296710-Middle Aged,
pubmed-meshheading:16296710-Nitroglycerin,
pubmed-meshheading:16296710-Physical Exertion,
pubmed-meshheading:16296710-Severity of Illness Index,
pubmed-meshheading:16296710-Time Factors,
pubmed-meshheading:16296710-Treatment Outcome,
pubmed-meshheading:16296710-Vasodilator Agents
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| pubmed:year |
1991
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| pubmed:articleTitle |
A 6-week double-blind comparison of amlodipine and placebo in patients with stable exertional angina pectoris receiving concomitant beta-blocker therapy.
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| pubmed:affiliation |
Med. Univ. Klinik, Graz, Austria.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Multicenter Study
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