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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-11-18
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pubmed:abstractText |
A murine segmental femoral bone graft model was used to show the essential role of donor periosteal progenitor cells in bone graft healing. Transplantation of live bone graft harvested from Rosa 26A mice showed that approximately 70% of osteogenesis on the graft was attributed to the expansion and differentiation of donor periosteal progenitor cells. Furthermore, engraftment of BMP-2-producing bone marrow stromal cells on nonvital allografts showed marked increases in cortical graft incorporation and neovascularization, suggesting that gene-enhanced, tissue engineered functional periosteum may improve allograft incorporation and repair.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/BMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0884-0431
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2124-37
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pubmed:dateRevised |
2009-4-28
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pubmed:meshHeading |
pubmed-meshheading:16294266-Acid Phosphatase,
pubmed-meshheading:16294266-Alkaline Phosphatase,
pubmed-meshheading:16294266-Animals,
pubmed-meshheading:16294266-Bone Marrow Transplantation,
pubmed-meshheading:16294266-Bone Morphogenetic Protein 2,
pubmed-meshheading:16294266-Bone Morphogenetic Proteins,
pubmed-meshheading:16294266-Bone Regeneration,
pubmed-meshheading:16294266-Bone Remodeling,
pubmed-meshheading:16294266-Bone Transplantation,
pubmed-meshheading:16294266-Bone and Bones,
pubmed-meshheading:16294266-Cartilage,
pubmed-meshheading:16294266-Cell Differentiation,
pubmed-meshheading:16294266-Cell Proliferation,
pubmed-meshheading:16294266-Gene Therapy,
pubmed-meshheading:16294266-Humans,
pubmed-meshheading:16294266-Isoenzymes,
pubmed-meshheading:16294266-Mesenchymal Stem Cells,
pubmed-meshheading:16294266-Mice,
pubmed-meshheading:16294266-Mice, Inbred C57BL,
pubmed-meshheading:16294266-Mice, Transgenic,
pubmed-meshheading:16294266-Neovascularization, Physiologic,
pubmed-meshheading:16294266-Osteogenesis,
pubmed-meshheading:16294266-Periosteum,
pubmed-meshheading:16294266-Stromal Cells,
pubmed-meshheading:16294266-Tissue Engineering,
pubmed-meshheading:16294266-Transfection,
pubmed-meshheading:16294266-Transforming Growth Factor beta
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pubmed:year |
2005
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pubmed:articleTitle |
Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering.
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pubmed:affiliation |
Department of Orthopaedics, University of Rochester Medical Center, New York, USA. Xinping_Zhang@URMC.rochester.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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