16294265

Source:http://linkedlifedata.com/resource/pubmed/id/16294265

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0029458, umls-concept:C0035820, umls-concept:C0245726, umls-concept:C1511545, umls-concept:C1517004
pubmed:issue	12
pubmed:dateCreated	2005-11-18
pubmed:abstractText	We show that mice lacking beta3 integrin are protected from OVX-induced bone loss. Using a lentiviral-based strategy to express beta3 mutants in beta3(-/-) mice, we also show that beta3(S752), but not beta3(Y747/Y759), is important for osteoclastic bone resorption in vivo.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AR 48812, http://linkedlifedata.com/resource/pubmed/grant/AR08586, http://linkedlifedata.com/resource/pubmed/grant/AR32788, http://linkedlifedata.com/resource/pubmed/grant/AR46523, http://linkedlifedata.com/resource/pubmed/grant/AR46852, http://linkedlifedata.com/resource/pubmed/grant/AR47846, http://linkedlifedata.com/resource/pubmed/grant/AR48853, http://linkedlifedata.com/resource/pubmed/grant/DK07120, http://linkedlifedata.com/resource/pubmed/grant/DK56341, http://linkedlifedata.com/resource/pubmed/grant/DK57586
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8610640
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase, http://linkedlifedata.com/resource/pubmed/chemical/Actins, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Integrin beta3, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Colony-Stimulating Factor, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/RANK Ligand, http://linkedlifedata.com/resource/pubmed/chemical/Receptor Activator of Nuclear..., http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF11A protein, human, http://linkedlifedata.com/resource/pubmed/chemical/TNFSF11 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Tnfrsf11a protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf11 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0884-0431
pubmed:author	pubmed-author:KitauraHidekiH, pubmed-author:NovackDeborah VeisDV, pubmed-author:RossF PatrickFP, pubmed-author:SandsMark SMS, pubmed-author:TeitelbaumSteven LSL, pubmed-author:ZhaoHaiboH
pubmed:issnType	Print
pubmed:volume	20
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2116-23
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:16294265-Acid Phosphatase, pubmed-meshheading:16294265-Actins, pubmed-meshheading:16294265-Animals, pubmed-meshheading:16294265-Bleeding Time, pubmed-meshheading:16294265-Blood Platelets, pubmed-meshheading:16294265-Bone Density, pubmed-meshheading:16294265-Bone Marrow Cells, pubmed-meshheading:16294265-Bone Marrow Transplantation, pubmed-meshheading:16294265-Bone Resorption, pubmed-meshheading:16294265-Carrier Proteins, pubmed-meshheading:16294265-Cell Differentiation, pubmed-meshheading:16294265-Disease Models, Animal, pubmed-meshheading:16294265-Female, pubmed-meshheading:16294265-Femur Head, pubmed-meshheading:16294265-Genetic Vectors, pubmed-meshheading:16294265-Humans, pubmed-meshheading:16294265-Integrin beta3, pubmed-meshheading:16294265-Isoenzymes, pubmed-meshheading:16294265-Lentivirus, pubmed-meshheading:16294265-Lumbar Vertebrae, pubmed-meshheading:16294265-Macrophage Colony-Stimulating Factor, pubmed-meshheading:16294265-Membrane Glycoproteins, pubmed-meshheading:16294265-Mice, pubmed-meshheading:16294265-Mice, Inbred C57BL, pubmed-meshheading:16294265-Mice, Knockout, pubmed-meshheading:16294265-Mutation, pubmed-meshheading:16294265-Osteoclasts, pubmed-meshheading:16294265-Osteoporosis, Postmenopausal, pubmed-meshheading:16294265-Ovariectomy, pubmed-meshheading:16294265-RANK Ligand, pubmed-meshheading:16294265-Receptor Activator of Nuclear Factor-kappa B, pubmed-meshheading:16294265-Tibia, pubmed-meshheading:16294265-Transfection
pubmed:year	2005
pubmed:articleTitle	Critical role of beta3 integrin in experimental postmenopausal osteoporosis.
pubmed:affiliation	Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA.
pubmed:publicationType	Journal Article, Research Support, N.I.H., Extramural