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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-28
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pubmed:abstractText |
Studies on the clinical course of familial ALS suggest that the duration of illness is relatively consistent for each mutation but variable among the different mutations. The authors analyzed the relative amount of mutant compared with normal SOD1 protein in the erythrocytes from 29 patients with ALS with 22 different mutations. Turnover of mutant SOD1 correlated with a shorter disease survival time.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1526-632X
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pubmed:author |
pubmed-author:AndersenP MPM,
pubmed-author:AoikeFF,
pubmed-author:FukadaKK,
pubmed-author:HamasakiTT,
pubmed-author:HirataSS,
pubmed-author:KatoTT,
pubmed-author:NaganoSS,
pubmed-author:NakagawaMM,
pubmed-author:NakanishiTT,
pubmed-author:NakanoRR,
pubmed-author:OgawaMM,
pubmed-author:OgawaYY,
pubmed-author:OhlWW,
pubmed-author:SakodaSS,
pubmed-author:SatoTT,
pubmed-author:ShimizuAA,
pubmed-author:SugaiFF,
pubmed-author:YamamotoYY,
pubmed-author:ZhouZZ
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1954-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16291929-Adult,
pubmed-meshheading:16291929-Age of Onset,
pubmed-meshheading:16291929-Aged,
pubmed-meshheading:16291929-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:16291929-Central Nervous System,
pubmed-meshheading:16291929-DNA Mutational Analysis,
pubmed-meshheading:16291929-Disease Progression,
pubmed-meshheading:16291929-Female,
pubmed-meshheading:16291929-Genetic Predisposition to Disease,
pubmed-meshheading:16291929-Genetic Testing,
pubmed-meshheading:16291929-Humans,
pubmed-meshheading:16291929-Male,
pubmed-meshheading:16291929-Middle Aged,
pubmed-meshheading:16291929-Motor Neurons,
pubmed-meshheading:16291929-Mutation,
pubmed-meshheading:16291929-Predictive Value of Tests,
pubmed-meshheading:16291929-Prognosis,
pubmed-meshheading:16291929-Superoxide Dismutase,
pubmed-meshheading:16291929-Survival Rate,
pubmed-meshheading:16291929-Time Factors
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pubmed:year |
2005
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pubmed:articleTitle |
Rapid disease progression correlates with instability of mutant SOD1 in familial ALS.
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pubmed:affiliation |
Department of Neurology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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