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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5 Suppl
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pubmed:dateCreated |
2005-11-18
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pubmed:abstractText |
The merozoite surface protein 1 (MSP-1) is expressed in all Plasmodium species and is considered a major malaria vaccine candidate. We found that MSP-1 from Plasmodium vivax (PvMSP-1) contains a region of significant sequence homology with the 190L subunit vaccine derived from the P. falciparum MSP-1. The fragment, termed Pv200L, was expressed as a recombinant protein in Escherichia coli (rPv200L) and used to asses its immunologic relevance as a vaccine target. A cross-sectional, seroepidemiologic study conducted in Buenaventura, Colombia showed that 52.2% (95% confidence interval [CI] = 39.8-64.3) of individuals previously exposed to P. vivax and 72.8% (95% CI = 61.8-82.1) of P. vivax-infected patients had IgG antibodies to rPv200L. Immunization of BALB/c mice and Aotus monkeys induced IgG antibodies (titer > 10(6)) that cross-reacted with P. vivax parasites. Immunized monkeys displayed partial protection against a challenge with P. vivax blood stages. Our results suggest that Pv200L is a new malaria vaccine subunit and deserves further testing.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Malaria Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Merozoite Surface Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Pv200 antigen, P vivax,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0002-9637
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16-24
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16291762-Amino Acid Sequence,
pubmed-meshheading:16291762-Animals,
pubmed-meshheading:16291762-Antibodies, Protozoan,
pubmed-meshheading:16291762-Antigens, Protozoan,
pubmed-meshheading:16291762-Antigens, Surface,
pubmed-meshheading:16291762-Cebidae,
pubmed-meshheading:16291762-Colombia,
pubmed-meshheading:16291762-Cross-Sectional Studies,
pubmed-meshheading:16291762-Escherichia coli,
pubmed-meshheading:16291762-Humans,
pubmed-meshheading:16291762-Immunization,
pubmed-meshheading:16291762-Immunoglobulin G,
pubmed-meshheading:16291762-Malaria, Vivax,
pubmed-meshheading:16291762-Malaria Vaccines,
pubmed-meshheading:16291762-Merozoite Surface Protein 1,
pubmed-meshheading:16291762-Mice,
pubmed-meshheading:16291762-Mice, Inbred BALB C,
pubmed-meshheading:16291762-Molecular Sequence Data,
pubmed-meshheading:16291762-Plasmodium vivax,
pubmed-meshheading:16291762-Recombinant Proteins,
pubmed-meshheading:16291762-Seroepidemiologic Studies
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pubmed:year |
2005
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pubmed:articleTitle |
Antigenicity, immunogenicity, and protective efficacy of Plasmodium vivax MSP1 PV200l: a potential malaria vaccine subunit.
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pubmed:affiliation |
Instituto de Inmunología and Fundacion Centro de Primates, Universidad del Valle, Cali, Colombia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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