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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-12-2
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pubmed:abstractText |
In order to gain insight into sensory processing modulating reproductive behavioral and endocrine changes, we have aimed at identifying afferent pathways to neurons synthesizing luteinizing hormone-releasing hormone (LHRH, also known as gonadotropin-releasing hormone [GnRH]), a key neurohormone of reproduction. Injection of conditional pseudorabies virus into the brain of an LHRH::CRE mouse line led to the identification of neuronal networks connected to LHRH neurons. Remarkably, and in contrast to established notions on the nature of LHRH neuronal inputs, our data identify major olfactory projection pathways originating from a discrete population of olfactory sensory neurons but fail to document any synaptic connectivity with the vomeronasal system. Accordingly, chemosensory modulation of LHRH neuronal activity and mating behavior are dramatically impaired in absence of olfactory function, while they appear unaffected in mouse mutants lacking vomeronasal signaling. Further visualization of afferents to LHRH neurons across the brain offers a unique opportunity to uncover complex polysynaptic circuits modulating reproduction and fertility.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cre recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide-Gated Cation...,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrases,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Sex Attractants,
http://linkedlifedata.com/resource/pubmed/chemical/TRPC Cation Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Trpc2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/dichlobanil,
http://linkedlifedata.com/resource/pubmed/chemical/tau Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
669-82
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16290037-Animals,
pubmed-meshheading:16290037-Brain,
pubmed-meshheading:16290037-Cyclic Nucleotide-Gated Cation Channels,
pubmed-meshheading:16290037-Female,
pubmed-meshheading:16290037-Fertility,
pubmed-meshheading:16290037-Gonadotropin-Releasing Hormone,
pubmed-meshheading:16290037-Green Fluorescent Proteins,
pubmed-meshheading:16290037-Herpesvirus 1, Suid,
pubmed-meshheading:16290037-Hypothalamus,
pubmed-meshheading:16290037-Integrases,
pubmed-meshheading:16290037-Ion Channels,
pubmed-meshheading:16290037-Male,
pubmed-meshheading:16290037-Mice,
pubmed-meshheading:16290037-Mice, Inbred C57BL,
pubmed-meshheading:16290037-Mice, Knockout,
pubmed-meshheading:16290037-Mice, Transgenic,
pubmed-meshheading:16290037-Mitogen-Activated Protein Kinases,
pubmed-meshheading:16290037-Neural Pathways,
pubmed-meshheading:16290037-Neurons,
pubmed-meshheading:16290037-Nitriles,
pubmed-meshheading:16290037-Olfactory Bulb,
pubmed-meshheading:16290037-Olfactory Mucosa,
pubmed-meshheading:16290037-Olfactory Pathways,
pubmed-meshheading:16290037-Phosphorylation,
pubmed-meshheading:16290037-Preoptic Area,
pubmed-meshheading:16290037-Reproduction,
pubmed-meshheading:16290037-Septum of Brain,
pubmed-meshheading:16290037-Sex Attractants,
pubmed-meshheading:16290037-Sexual Behavior, Animal,
pubmed-meshheading:16290037-TRPC Cation Channels,
pubmed-meshheading:16290037-Thymidine Kinase,
pubmed-meshheading:16290037-Vomeronasal Organ,
pubmed-meshheading:16290037-tau Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Olfactory inputs to hypothalamic neurons controlling reproduction and fertility.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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