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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-3-14
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pubmed:abstractText |
We present a new mouse model for the study of peritoneal adhesions using macrophage Fas-induced apoptosis (Mafia) transgenic mice expressing a Fas-FKBP construct under control of the murine c-fms promoter. Mafia mice allow systemic macrophage depletion by dimerization of Fas with a synthetic dimerizer, AP20187. Results demonstrate that macrophage depletion in Mafia mice induces peritoneal adhesion formation when the peritoneal cavity is also exposed to an irritant. The Mafia mouse model presents a reproducible, non-surgical approach for research in adhesion formation and prevention.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
296-301
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16289593-Animals,
pubmed-meshheading:16289593-Apoptosis,
pubmed-meshheading:16289593-Disease Models, Animal,
pubmed-meshheading:16289593-Fas Ligand Protein,
pubmed-meshheading:16289593-Genes, fms,
pubmed-meshheading:16289593-Macrophages,
pubmed-meshheading:16289593-Membrane Glycoproteins,
pubmed-meshheading:16289593-Mice,
pubmed-meshheading:16289593-Mice, Inbred C57BL,
pubmed-meshheading:16289593-Mice, Transgenic,
pubmed-meshheading:16289593-Peritoneal Diseases,
pubmed-meshheading:16289593-Tacrolimus,
pubmed-meshheading:16289593-Tissue Adhesions,
pubmed-meshheading:16289593-Tumor Necrosis Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Development of peritoneal adhesions in macrophage depleted mice.
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pubmed:affiliation |
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah 84602, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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