rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-2-28
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pubmed:abstractText |
Progesterone and glucocorticoids such as dexamethasone mediate distinct biological functions, yet they bind to receptors that recognize the same consensus DNA response element. In breast cancer, progestins are associated with the incidence and progression of tumors, whereas glucocorticoids are growth-suppressive in mammary cancer cells; the differential effects of these two steroids are less well understood in the hormone-dependent disease cancer of the uterine endometrium. We set out to identify genes that are regulated by progesterone through progesterone receptors and dexamethasone through glucocorticoid receptors in a well-differentiated human endometrial cancer cell line.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/CDH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/USF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Upstream Stimulatory Factors,
http://linkedlifedata.com/resource/pubmed/chemical/asparaginylendopeptidase
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0090-8258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
62-70
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16289307-Antigens, CD,
pubmed-meshheading:16289307-Cadherins,
pubmed-meshheading:16289307-Cysteine Endopeptidases,
pubmed-meshheading:16289307-Dexamethasone,
pubmed-meshheading:16289307-Endometrial Neoplasms,
pubmed-meshheading:16289307-Female,
pubmed-meshheading:16289307-Gene Expression Profiling,
pubmed-meshheading:16289307-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16289307-Humans,
pubmed-meshheading:16289307-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16289307-Progesterone,
pubmed-meshheading:16289307-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16289307-Upstream Stimulatory Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Gene regulation profiles by progesterone and dexamethasone in human endometrial cancer Ishikawa H cells.
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pubmed:affiliation |
Reproductive Molecular Biology Laboratory, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131-5286, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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