Source:http://linkedlifedata.com/resource/pubmed/id/16288717
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2005-11-23
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pubmed:abstractText |
Immune system modulates atherosclerosis and immunization using homologous LDL reduces atherosclerosis in hyperlipidemic animals. The nature of athero-protective antigenic epitopes in LDL remains unclear. We have recently identified nearly a 100 antigenic epitopes in human apo B-100 and in this study we evaluated the effects of immunization with two such epitopes on atherosclerosis in hypercholesterolemic apo E (-/-) mice. Male apo E (-/-) mice were immunized at 6-7 weeks of age with two different apo B-100 related peptide sequences using alum as adjuvant and mice immunized with alum alone served as controls. Peptide-2 immunization reduced aortic atherosclerosis by 40% and plaque inflammation by 80% compared to controls without a reduction in circulating cholesterol levels whereas Peptide-1 immunization had no effect. Peptide-2 immunization also reduced the progression of aortic lesions when mice were immunized at 16 weeks of age, suggesting the possibility of immuno-modulation in treating established atherosclerosis. The athero-protective effect of Peptide-2 immunization was absent in splenectomized mice but could be conveyed to non-immunized mice via adoptive transfer of splenocytes from peptide-2 immunized mice. In conclusion, immunization with a specific apo B-100 related peptide sequence reduces aortic atherosclerosis and plaque inflammation. Such acquired immunity and athero-protective effect appears to be mediated by splenocytes. These data demonstrate the feasibility of peptide based immunomodulating therapy for atherosclerosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein B-100,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-291X
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pubmed:author |
pubmed-author:BabbidgeStephanie MSM,
pubmed-author:CercekBojanB,
pubmed-author:ChyuKuang-YuhKY,
pubmed-author:DimayugaPaul CPC,
pubmed-author:FredriksonGunilla NordinGN,
pubmed-author:NilssonJanJ,
pubmed-author:ReyesOdette SOS,
pubmed-author:ShahPrediman KPK,
pubmed-author:YanoJulianaJ,
pubmed-author:ZhaoXiaoningX
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
338
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1982-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16288717-Adoptive Transfer,
pubmed-meshheading:16288717-Animals,
pubmed-meshheading:16288717-Apolipoprotein B-100,
pubmed-meshheading:16288717-Apolipoproteins B,
pubmed-meshheading:16288717-Apolipoproteins E,
pubmed-meshheading:16288717-Atherosclerosis,
pubmed-meshheading:16288717-Cholesterol,
pubmed-meshheading:16288717-Epitopes,
pubmed-meshheading:16288717-Hypercholesterolemia,
pubmed-meshheading:16288717-Immunization,
pubmed-meshheading:16288717-Immunotherapy, Adoptive,
pubmed-meshheading:16288717-Inflammation,
pubmed-meshheading:16288717-Male,
pubmed-meshheading:16288717-Mice,
pubmed-meshheading:16288717-Spleen
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pubmed:year |
2005
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pubmed:articleTitle |
Immunization using an Apo B-100 related epitope reduces atherosclerosis and plaque inflammation in hypercholesterolemic apo E (-/-) mice.
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pubmed:affiliation |
Atherosclerosis Research Center, Division of Cardiology, Department of Medicine and Burns and Allen Research Institute, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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