Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-11-18
pubmed:abstractText
The rapid institution of empirical broad-spectrum antibiotics has become the gold standard of treatment for febrile neutropenic children undergoing therapy for cancer. With this approach, morbidity and mortality have dropped significantly but have not been eliminated altogether. In recent randomized studies evaluating different drug combinations, there is still a 3-10 % mortality reported in febrile, neutropenic cancer events. Despite improvements in invasive and non-invasive diagnostic procedures, a majority of patients will receive antibiotic therapy despite an inability to identify a specific pathogen or source (fever of unknown origin, FUO). While there are evidence-based guidelines in adult patients with fever and neutropenia, data are less clear in the pediatric population. Experts agree on the early use of empirical antibiotic therapy, which covers Pseudomonas spp. and is initiated at the first sign of fever. The success of this approach has been based upon clinical intervention before the results of the diagnostic evaluation are available. In contrast, the use of aminoglycosides or glycopeptides is still a matter of debate, as it is the duration of antibiotic therapy. Based on published data in pediatric and adult patients with cancer, the current diagnostic procedures and therapeutic strategies will are discussed. The recommendations given are a consensus of the German Society of Pediatric Oncology and Hematology (GPOH) and the German Society of Pediatric Infectious Diseases (DGPI).
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0300-8630
pubmed:author
pubmed:issnType
Print
pubmed:volume
217 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S9-16
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16288350-Administration, Oral, pubmed-meshheading:16288350-Adolescent, pubmed-meshheading:16288350-Anti-Bacterial Agents, pubmed-meshheading:16288350-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:16288350-Child, pubmed-meshheading:16288350-Drug Therapy, Combination, pubmed-meshheading:16288350-Empiricism, pubmed-meshheading:16288350-Fever of Unknown Origin, pubmed-meshheading:16288350-Humans, pubmed-meshheading:16288350-Infusions, Intravenous, pubmed-meshheading:16288350-Microbial Sensitivity Tests, pubmed-meshheading:16288350-Neoplasms, pubmed-meshheading:16288350-Neutropenia, pubmed-meshheading:16288350-Opportunistic Infections, pubmed-meshheading:16288350-Practice Guidelines as Topic, pubmed-meshheading:16288350-Prognosis, pubmed-meshheading:16288350-Survival Rate
pubmed:year
2005
pubmed:articleTitle
[Diagnostic procedures and management of Fever in pediatric cancer patients].
pubmed:affiliation
Klinik für Kinder-Onkologie, -Hämatologie und -Immunologie, Universitätsklinikum Düsseldorf. laws@med.uni-duesseldorf.de
pubmed:publicationType
Journal Article, English Abstract, Review