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| pubmed-article:1628829 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:1628829 | lifeskim:mentions | umls-concept:C0025646 | lld:lifeskim |
| pubmed-article:1628829 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:1628829 | lifeskim:mentions | umls-concept:C0871712 | lld:lifeskim |
| pubmed-article:1628829 | lifeskim:mentions | umls-concept:C1519616 | lld:lifeskim |
| pubmed-article:1628829 | lifeskim:mentions | umls-concept:C0162339 | lld:lifeskim |
| pubmed-article:1628829 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:1628829 | pubmed:dateCreated | 1992-8-14 | lld:pubmed |
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| pubmed-article:1628829 | pubmed:abstractText | c-myc belongs to a small, yet growing, group of eukaryotic mRNAs that initiate translation inefficiently from a non-AUG codon upstream from a more efficient AUG codon. We have examined the translational regulation of non-AUG-initiated c-myc 1 and AUG-initiated c-myc 2 protein synthesis in avian and mouse cells during proliferation. As lymphoid, erythroid, and embryo fibroblast cells approached high densities in culture, there was a sustained 5- to 10-fold induction in the synthesis of c-myc 1 protein to levels greater than or equal to c-myc 2 protein synthesis. Treatment with conditioned/depleted media from high-density cells was able to reproduce this activation in low-density cells within 5 hr. Additional studies with the conditioned/depleted media revealed that amino acid availability, specifically methionine deprivation, was responsible for this unique translational control. Our results describe a specific and dramatic regulation of dual translational initiation. Furthermore, these results represent a novel translational activation of a specific gene in higher eukaryotes in response to nutrient deprivation. | lld:pubmed |
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| pubmed-article:1628829 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1628829 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1628829 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1628829 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1628829 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:1628829 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:1628829 | pubmed:author | pubmed-author:HannS RSR | lld:pubmed |
| pubmed-article:1628829 | pubmed:author | pubmed-author:SpottsG DGD | lld:pubmed |
| pubmed-article:1628829 | pubmed:author | pubmed-author:Sloan-BrownKK | lld:pubmed |
| pubmed-article:1628829 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1628829 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:1628829 | pubmed:geneSymbol | c-myc | lld:pubmed |
| pubmed-article:1628829 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1628829 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1628829 | pubmed:pagination | 1229-40 | lld:pubmed |
| pubmed-article:1628829 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1628829 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1628829 | pubmed:articleTitle | Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation. | lld:pubmed |
| pubmed-article:1628829 | pubmed:affiliation | Department of Cell Biology, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232-2175. | lld:pubmed |
| pubmed-article:1628829 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1628829 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1628829 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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