| pubmed-article:16288291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C1523298 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:16288291 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:16288291 | pubmed:issue | 50 | lld:pubmed |
| pubmed-article:16288291 | pubmed:dateCreated | 2005-11-18 | lld:pubmed |
| pubmed-article:16288291 | pubmed:abstractText | Epithelial-mesenchymal transition (EMT) is an important process during development by which epithelial cells acquire mesenchymal, fibroblast-like properties and show reduced intercellular adhesion and increased motility. Accumulating evidence points to a critical role of EMT-like events during tumor progression and malignant transformation, endowing the incipient cancer cell with invasive and metastatic properties. Several oncogenic pathways (peptide growth factors, Src, Ras, Ets, integrin, Wnt/beta-catenin and Notch) induce EMT and a critical molecular event is the downregulation of the cell adhesion molecule E-cadherin. Recently, activation of the phosphatidylinositol 3' kinase (PI3K)/AKT axis is emerging as a central feature of EMT. In this review, we discuss the role of PI3K/AKT pathways in EMT during development and cancer with a focus on E-cadherin regulation. Interactions between PI3K/AKT and other EMT-inducing pathways are presented, along with a discussion of the therapeutic implications of modulating EMT in order to achieve cancer control. | lld:pubmed |
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| pubmed-article:16288291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16288291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16288291 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16288291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16288291 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16288291 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:16288291 | pubmed:author | pubmed-author:LarueLionelL | lld:pubmed |
| pubmed-article:16288291 | pubmed:author | pubmed-author:BellacosaAlfo... | lld:pubmed |
| pubmed-article:16288291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16288291 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:16288291 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:16288291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16288291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16288291 | pubmed:pagination | 7443-54 | lld:pubmed |
| pubmed-article:16288291 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:meshHeading | pubmed-meshheading:16288291... | lld:pubmed |
| pubmed-article:16288291 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16288291 | pubmed:articleTitle | Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. | lld:pubmed |
| pubmed-article:16288291 | pubmed:affiliation | Developmental Genetics of Melanocytes, UMR 146, CNRS, Institut Curie, Centre Universitaire, Orsay, France. lionel.larue@curie.fr | lld:pubmed |
| pubmed-article:16288291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16288291 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:16288291 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16288291 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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