Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2005-11-18
pubmed:abstractText
Placental development initially occurs in a low-oxygen (O2) or hypoxic environment. In this report we show that two hypoxia-inducible factors (HIFs), HIF1alpha and HIF2alpha, are essential for determining murine placental cell fates. HIF is a heterodimer composed of HIFalpha and HIFbeta (ARNT) subunits. Placentas from Arnt-/- and Hif1alpha-/- Hif2alpha-/- embryos exhibit defective placental vascularization and aberrant cell fate adoption. HIF regulation of Mash2 promotes spongiotrophoblast differentiation, a prerequisite for trophoblast giant cell differentiation. In the absence of Arnt or Hifalpha, trophoblast stem cells fail to generate these cell types and become labyrinthine trophoblasts instead. Therefore, HIF mediates placental morphogenesis, angiogenesis, and cell fate decisions, demonstrating that O2 tension is a critical regulator of trophoblast lineage determination. This novel genetic approach provides new insights into the role of O2 tension in the development of life-threatening pregnancy-related diseases such as preeclampsia.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10021343, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10229225, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10353251, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10377170, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10521392, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10712429, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10821478, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10823831, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10836146, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10869528, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10873707, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10878807, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10880563, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-10906065, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-11043580, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-11114720, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-11124810, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-11437448, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-11988332, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-12017545, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-12053176, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-12466296, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-12832481, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-12917334, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-14559790, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-14580376, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-14645546, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-14659802, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-15033304, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-15196947, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-15689487, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-15753215, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-1635745, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-7539918, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-7773285, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-7985020, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-8090202, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-8589438, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9000051, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9113979, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9121557, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9398442, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9436976, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9500551, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9545558, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9606183, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9697772, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9806910, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9808618, http://linkedlifedata.com/resource/pubmed/commentcorrection/16287860-9851926
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10479-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation.
pubmed:affiliation
The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, Belgium.
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