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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-11-15
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pubmed:abstractText |
Little is known about the molecular mechanisms of learned and innate fear. We have identified stathmin, an inhibitor of microtubule formation, as highly expressed in the lateral nucleus (LA) of the amygdala as well as in the thalamic and cortical structures that send information to the LA about the conditioned (learned fear) and unconditioned stimuli (innate fear). Whole-cell recordings from amygdala slices that are isolated from stathmin knockout mice show deficits in spike-timing-dependent long-term potentiation (LTP). The knockout mice also exhibit decreased memory in amygdala-dependent fear conditioning and fail to recognize danger in innately aversive environments. By contrast, these mice do not show deficits in the water maze, a spatial task dependent on the hippocampus, where stathmin is not normally expressed. We therefore conclude that stathmin is required for the induction of LTP in afferent inputs to the amygdala and is essential in regulating both innate and learned fear.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:BolshakovVadim YVY,
pubmed-author:JosephJamieJ,
pubmed-author:KandelEric RER,
pubmed-author:MalleretGaëlG,
pubmed-author:SchubartUlrich KUK,
pubmed-author:ShinRyong-MoonRM,
pubmed-author:ShumyatskyGleb PGP,
pubmed-author:TakizawaShuichiS,
pubmed-author:TsvetkovEvgenyE,
pubmed-author:TullyKeithK,
pubmed-author:VronskayaSvetlanaS,
pubmed-author:YinDeQiD,
pubmed-author:ZakharenkoStanislav SSS
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
697-709
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16286011-Amygdala,
pubmed-meshheading:16286011-Animals,
pubmed-meshheading:16286011-Animals, Newborn,
pubmed-meshheading:16286011-Behavior, Animal,
pubmed-meshheading:16286011-Cerebral Cortex,
pubmed-meshheading:16286011-Conditioning (Psychology),
pubmed-meshheading:16286011-Electrophysiology,
pubmed-meshheading:16286011-Fear,
pubmed-meshheading:16286011-Gene Expression,
pubmed-meshheading:16286011-Gene Expression Regulation, Developmental,
pubmed-meshheading:16286011-Hippocampus,
pubmed-meshheading:16286011-Immunohistochemistry,
pubmed-meshheading:16286011-In Situ Hybridization,
pubmed-meshheading:16286011-Long-Term Potentiation,
pubmed-meshheading:16286011-Maze Learning,
pubmed-meshheading:16286011-Memory Disorders,
pubmed-meshheading:16286011-Mice,
pubmed-meshheading:16286011-Mice, Knockout,
pubmed-meshheading:16286011-Microtubules,
pubmed-meshheading:16286011-Neural Pathways,
pubmed-meshheading:16286011-Neurons,
pubmed-meshheading:16286011-Receptors, GABA-A,
pubmed-meshheading:16286011-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:16286011-Stathmin,
pubmed-meshheading:16286011-Synaptic Transmission,
pubmed-meshheading:16286011-Thalamus,
pubmed-meshheading:16286011-Time Factors,
pubmed-meshheading:16286011-Tubulin
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pubmed:year |
2005
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pubmed:articleTitle |
stathmin, a gene enriched in the amygdala, controls both learned and innate fear.
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pubmed:affiliation |
Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA. gleb@biology.rutgers.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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