| pubmed-article:16286010 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16286010 | lifeskim:mentions | umls-concept:C0231448 | lld:lifeskim |
| pubmed-article:16286010 | lifeskim:mentions | umls-concept:C1149630 | lld:lifeskim |
| pubmed-article:16286010 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:16286010 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16286010 | pubmed:dateCreated | 2005-11-15 | lld:pubmed |
| pubmed-article:16286010 | pubmed:abstractText | Sir2 is a conserved deacetylase that modulates life span in yeast, worms, and flies and stress response in mammals. In yeast, Sir2 is required for maintaining replicative life span, and increasing Sir2 dosage can delay replicative aging. We address the role of Sir2 in regulating chronological life span in yeast. Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological life-span extension. Inactivation of Sir2 causes uptake and catabolism of ethanol and upregulation of many stress-resistance and sporulation genes. These changes while sufficient to extend chronological life span in wild-type yeast require severe calorie restriction or additional mutations to extend life span of sir2Delta mutants. Our results demonstrate that effects of SIR2 on chronological life span are opposite to replicatve life span and suggest that the relevant activities of Sir2-like deacetylases may also be complex in higher eukaryotes. | lld:pubmed |
| pubmed-article:16286010 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16286010 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16286010 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16286010 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16286010 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:16286010 | pubmed:author | pubmed-author:ChengChaoC | lld:pubmed |
| pubmed-article:16286010 | pubmed:author | pubmed-author:WeiMinM | lld:pubmed |
| pubmed-article:16286010 | pubmed:author | pubmed-author:FabrizioPaola... | lld:pubmed |
| pubmed-article:16286010 | pubmed:author | pubmed-author:LongoValter... | lld:pubmed |
| pubmed-article:16286010 | pubmed:author | pubmed-author:BattistellaLu... | lld:pubmed |
| pubmed-article:16286010 | pubmed:author | pubmed-author:GattazzoCrist... | lld:pubmed |
| pubmed-article:16286010 | pubmed:author | pubmed-author:McGrewKristen... | lld:pubmed |
| pubmed-article:16286010 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16286010 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:16286010 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:16286010 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16286010 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16286010 | pubmed:pagination | 655-67 | lld:pubmed |
| pubmed-article:16286010 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:meshHeading | pubmed-meshheading:16286010... | lld:pubmed |
| pubmed-article:16286010 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16286010 | pubmed:articleTitle | Sir2 blocks extreme life-span extension. | lld:pubmed |
| pubmed-article:16286010 | pubmed:affiliation | Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA. | lld:pubmed |
| pubmed-article:16286010 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16286010 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16286010 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:851520 | entrezgene:pubmed | pubmed-article:16286010 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16286010 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16286010 | lld:pubmed |
