Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-11-15
pubmed:abstractText
Sir2 is a conserved deacetylase that modulates life span in yeast, worms, and flies and stress response in mammals. In yeast, Sir2 is required for maintaining replicative life span, and increasing Sir2 dosage can delay replicative aging. We address the role of Sir2 in regulating chronological life span in yeast. Lack of Sir2 along with calorie restriction and/or mutations in the yeast AKT homolog, Sch9, or Ras pathways causes a dramatic chronological life-span extension. Inactivation of Sir2 causes uptake and catabolism of ethanol and upregulation of many stress-resistance and sporulation genes. These changes while sufficient to extend chronological life span in wild-type yeast require severe calorie restriction or additional mutations to extend life span of sir2Delta mutants. Our results demonstrate that effects of SIR2 on chronological life span are opposite to replicatve life span and suggest that the relevant activities of Sir2-like deacetylases may also be complex in higher eukaryotes.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase, http://linkedlifedata.com/resource/pubmed/chemical/Alcohol Dehydrogenase, http://linkedlifedata.com/resource/pubmed/chemical/Ethanol, http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases, http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/SCH9 protein kinase, http://linkedlifedata.com/resource/pubmed/chemical/SIR2 protein, S cerevisiae, http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Silent Information Regulator..., http://linkedlifedata.com/resource/pubmed/chemical/Sirtuin 2, http://linkedlifedata.com/resource/pubmed/chemical/Sirtuins, http://linkedlifedata.com/resource/pubmed/chemical/Vitamin K 3
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
18
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
655-67
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16286010-Adenylate Cyclase, pubmed-meshheading:16286010-Alcohol Dehydrogenase, pubmed-meshheading:16286010-DNA Repair, pubmed-meshheading:16286010-Down-Regulation, pubmed-meshheading:16286010-Ethanol, pubmed-meshheading:16286010-Gene Deletion, pubmed-meshheading:16286010-Gene Expression Profiling, pubmed-meshheading:16286010-Gene Expression Regulation, Fungal, pubmed-meshheading:16286010-Histone Deacetylases, pubmed-meshheading:16286010-Hot Temperature, pubmed-meshheading:16286010-Hydrogen Peroxide, pubmed-meshheading:16286010-Models, Biological, pubmed-meshheading:16286010-Mutation, pubmed-meshheading:16286010-Oxidative Stress, pubmed-meshheading:16286010-Protein Kinases, pubmed-meshheading:16286010-Saccharomyces cerevisiae, pubmed-meshheading:16286010-Saccharomyces cerevisiae Proteins, pubmed-meshheading:16286010-Silent Information Regulator Proteins, Saccharomyces..., pubmed-meshheading:16286010-Sirtuin 2, pubmed-meshheading:16286010-Sirtuins, pubmed-meshheading:16286010-Time Factors, pubmed-meshheading:16286010-Up-Regulation, pubmed-meshheading:16286010-Vitamin K 3
pubmed:year
2005
pubmed:articleTitle
Sir2 blocks extreme life-span extension.
pubmed:affiliation
Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural