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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5750
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pubmed:dateCreated |
2005-11-14
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pubmed:databankReference |
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pubmed:abstractText |
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant and contains features essential for coreceptor binding. We determined the structure of V3 in the context of an HIV-1 gp120 core complexed to the CD4 receptor and to the X5 antibody at 3.5 angstrom resolution. Binding of gp120 to cell-surface CD4 would position V3 so that its coreceptor-binding tip protrudes 30 angstroms from the core toward the target cell membrane. The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-10644369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-10826481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-11188697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-11356961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-11463918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-11543657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-11997472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-12163614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-12646921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-12954207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-14592768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-14769016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-15613343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-15725757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-15729334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-15768031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-15893666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-1701030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-1703322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-1713252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-1905842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-2247146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-6096719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-8474162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-8629022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-8906795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-8906796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-9168119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-9632381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-9632396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-9641677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-9641684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-9658072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16284180-9933605
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp120,
http://linkedlifedata.com/resource/pubmed/chemical/HIV envelope protein gp120 (305-321),
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR5,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR4
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:DimitrovDimiter SDS,
pubmed-author:HuangChih-chinCC,
pubmed-author:KorberBetteB,
pubmed-author:KwongPeter DPD,
pubmed-author:MajeedShahzadS,
pubmed-author:MontabanaElizabethE,
pubmed-author:SodroskiJosephJ,
pubmed-author:StanfieldRobyn LRL,
pubmed-author:TangMinM,
pubmed-author:WilsonIan AIA,
pubmed-author:WyattRichardR,
pubmed-author:ZhangMei-YunMY
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
310
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1025-8
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pubmed:dateRevised |
2011-9-19
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pubmed:meshHeading |
pubmed-meshheading:16284180-Humans,
pubmed-meshheading:16284180-Crystallization,
pubmed-meshheading:16284180-Peptide Fragments,
pubmed-meshheading:16284180-Crystallography, X-Ray,
pubmed-meshheading:16284180-Models, Molecular,
pubmed-meshheading:16284180-Protein Conformation,
pubmed-meshheading:16284180-Amino Acid Sequence,
pubmed-meshheading:16284180-Protein Binding,
pubmed-meshheading:16284180-Binding Sites,
pubmed-meshheading:16284180-Molecular Sequence Data,
pubmed-meshheading:16284180-Hydrogen Bonding,
pubmed-meshheading:16284180-Protein Structure, Tertiary,
pubmed-meshheading:16284180-HIV Antibodies,
pubmed-meshheading:16284180-HIV-1,
pubmed-meshheading:16284180-HIV Envelope Protein gp120,
pubmed-meshheading:16284180-Antigens, CD4,
pubmed-meshheading:16284180-Immunodominant Epitopes,
pubmed-meshheading:16284180-Receptors, CCR5,
pubmed-meshheading:16284180-Receptors, CXCR4
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