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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-11-11
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pubmed:abstractText |
PCK3145 is a synthetic peptide corresponding to amino acids 31-45 of prostate secretory protein 94, which can reduce experimental skeletal metastases and prostate tumor growth in vivo. Part of its biological action involves the reduction of circulating plasma matrix metalloproteinase (MMP)-9, a crucial mediator in extracellular matrix (ECM) degradation during tumor metastasis and cancer cell invasion. The antimetastatic mechanism of action of PCK3145 is however, not understood.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0262-0898
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pubmed:author |
pubmed-author:AnnabiBorhaneB,
pubmed-author:BéliveauRichardR,
pubmed-author:BouzeghraneMouniaM,
pubmed-author:CurrieJean-ChristopheJC,
pubmed-author:DaigneaultLucL,
pubmed-author:DuludeHélèneH,
pubmed-author:GardeSeemaS,
pubmed-author:HawkinsRobertR,
pubmed-author:PanchalChandraC,
pubmed-author:RabbaniShafaat ASA,
pubmed-author:RuizMarciaM,
pubmed-author:WisniewskiJanJ,
pubmed-author:WuJinzi JJJ
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
429-39
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pubmed:dateRevised |
2008-8-14
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pubmed:meshHeading |
pubmed-meshheading:16283486-Antigens, CD44,
pubmed-meshheading:16283486-Fibrosarcoma,
pubmed-meshheading:16283486-Flow Cytometry,
pubmed-meshheading:16283486-Gene Expression Profiling,
pubmed-meshheading:16283486-Humans,
pubmed-meshheading:16283486-Matrix Metalloproteinase 9,
pubmed-meshheading:16283486-Neoplasm Metastasis,
pubmed-meshheading:16283486-Peptide Fragments,
pubmed-meshheading:16283486-Polyesters,
pubmed-meshheading:16283486-Prostatic Secretory Proteins,
pubmed-meshheading:16283486-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16283486-Tumor Cells, Cultured
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pubmed:year |
2005
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pubmed:articleTitle |
A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis.
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pubmed:affiliation |
Laboratoire d'Oncologie Moléculaire, Département de Chimie-Biochimie, Université du Québec à Montréal, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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