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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2005-11-11
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pubmed:abstractText |
The epidermal growth factor receptor (EGFR) is frequently amplified, overexpressed, or mutated in glioblastomas, but only 10 to 20 percent of patients have a response to EGFR kinase inhibitors. The mechanism of responsiveness of glioblastomas to these inhibitors is unknown.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/PTEN Phosphohydrolase,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/epidermal growth factor receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/erlotinib,
http://linkedlifedata.com/resource/pubmed/chemical/gefitinib
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1533-4406
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pubmed:author |
pubmed-author:BeroukhimRameenR,
pubmed-author:CaveneeWebster KWK,
pubmed-author:ChuteDennis JDJ,
pubmed-author:CloughesyTimothy FTF,
pubmed-author:DiaEderlyn QEQ,
pubmed-author:Haas-KoganDaphne ADA,
pubmed-author:HorvathSteveS,
pubmed-author:HuangJulie H YJH,
pubmed-author:LeeJeffrey CJC,
pubmed-author:LiauLinda MLM,
pubmed-author:LuKan VKV,
pubmed-author:MellinghoffIngo KIK,
pubmed-author:MischelPaul SPS,
pubmed-author:PeckTimothy CTC,
pubmed-author:PradosMichaelM,
pubmed-author:RaoP NageshPN,
pubmed-author:RiggsBridget LBL,
pubmed-author:SawyersCharles LCL,
pubmed-author:SellersWilliam RWR,
pubmed-author:StokoeDavidD,
pubmed-author:VivancoIgorI,
pubmed-author:WangMaria YMY,
pubmed-author:YoshimotoKojiK,
pubmed-author:ZhuShaojunS
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pubmed:copyrightInfo |
Copyright 2005 Massachusetts Medical Society.
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
353
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2012-24
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16282176-Adult,
pubmed-meshheading:16282176-Aged,
pubmed-meshheading:16282176-Antineoplastic Agents,
pubmed-meshheading:16282176-DNA, Neoplasm,
pubmed-meshheading:16282176-Female,
pubmed-meshheading:16282176-Gene Amplification,
pubmed-meshheading:16282176-Gene Deletion,
pubmed-meshheading:16282176-Gene Expression,
pubmed-meshheading:16282176-Genes, erbB-1,
pubmed-meshheading:16282176-Genes, erbB-2,
pubmed-meshheading:16282176-Glioblastoma,
pubmed-meshheading:16282176-Humans,
pubmed-meshheading:16282176-Male,
pubmed-meshheading:16282176-Middle Aged,
pubmed-meshheading:16282176-Mutation,
pubmed-meshheading:16282176-Oligodendroglioma,
pubmed-meshheading:16282176-PTEN Phosphohydrolase,
pubmed-meshheading:16282176-Polymerase Chain Reaction,
pubmed-meshheading:16282176-Protein Kinase Inhibitors,
pubmed-meshheading:16282176-Quinazolines,
pubmed-meshheading:16282176-Receptor, Epidermal Growth Factor,
pubmed-meshheading:16282176-Sequence Analysis, DNA,
pubmed-meshheading:16282176-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
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pubmed:affiliation |
Department of Molecular and Medical Pharmacology and Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles 90095-1732, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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