Linked Life Data

1628215

Source:http://linkedlifedata.com/resource/pubmed/id/1628215

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1992-8-18
pubmed:abstractText
Unilateral lesioning of the rat locus coeruleus by an electric current (0.3 mA/10 s) reduces the ipsilateral hippocampal tissue content of dopamine (DA) and noradrenaline (NA) by 80% and 60% respectively, and protects against the excitotoxic action of bilateral kainate injections (1.1 nmol/microliters) in the hippocampus. On the ipsilateral side hippocampal CA1, CA2 and DG cells were protected; lesser protection of CA1 cells was seen on the contralateral side. The unilateral injection of 6-hydroxydopamine (8.8 micrograms/2 microliters/5 min) into the medial forebrain bundle abolishes the increase in extracellular NA concentration induced by kainate in the ipsilateral hippocampus without altering the low extracellular DA levels. This medial forebrain bundle lesion protects (on the ipsilateral side) against kainate toxicity (500 microM through the probe for 20 min) in the hippocampus (CA1, CA2 and DG cells). The noradrenergic innervation of the hippocampus apparently potentiates the excitotoxic effect of focal injection of kainate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
579
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
279-84
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Electrolytic lesions of the locus coeruleus or 6-hydroxydopamine lesions of the medial forebrain bundle protect against excitotoxic damage in rat hippocampus.
pubmed:affiliation
Department of Neurology, Institute of Psychiatry, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't