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pubmed:abstractText |
It is known that aurora B, a chromosomal passenger protein responsible for the proper progression of mitosis and cytokinesis, is overexpressed throughout the cell cycle in cancer cells. Overexpression of aurora B produced multinuclearity and induced aggressive metastasis, suggesting that overexpressed aurora B has multiple functions in cancer development. However, the detailed dynamics and functions of overexpressed aurora B are poorly understood.
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pubmed:affiliation |
Mammalian Cell Biology Group, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, 117604, Singapore. makihori@tll.org.sg
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