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rdf:type |
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lifeskim:mentions |
umls-concept:C0004811,
umls-concept:C0026336,
umls-concept:C0027758,
umls-concept:C0033634,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0085616,
umls-concept:C0228174,
umls-concept:C1335797,
umls-concept:C1419781,
umls-concept:C1419790,
umls-concept:C1706144,
umls-concept:C1719914,
umls-concept:C1720127,
umls-concept:C2828406
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pubmed:issue |
6
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pubmed:dateCreated |
2005-11-11
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pubmed:abstractText |
The cellular events leading to cerebral vasospasm after subarachnoid haemorrhages (SAH) involve a number of members of the protein kinase C (PKC) family. However, whereas calcium is thought to play a number of major roles in the pathophysiology of SAH, a number of PKCs function independently of calcium. We recently emphasized the potential role of the calcium-binding S100 proteins in a 'double haemorrhage' rat model of SAH-induced vasospasm. A number of S100 proteins are known to interfere directly with PKC, or indirectly with PKC substrates. We therefore investigated whether specific S100 proteins and PKCs are co-expressed/co-located in a rat model of SAH-induced vasospasm.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/S-100 calcium-binding protein beta...,
http://linkedlifedata.com/resource/pubmed/chemical/S100 Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/S100A1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/S100A2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C beta,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C eta,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase C zeta
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0305-1846
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
649-60
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16281914-Animals,
pubmed-meshheading:16281914-Basilar Artery,
pubmed-meshheading:16281914-Blotting, Western,
pubmed-meshheading:16281914-Calcium-Binding Proteins,
pubmed-meshheading:16281914-Chemotactic Factors,
pubmed-meshheading:16281914-Disease Models, Animal,
pubmed-meshheading:16281914-Nerve Growth Factors,
pubmed-meshheading:16281914-Protein Kinase C,
pubmed-meshheading:16281914-Protein Kinase C-alpha,
pubmed-meshheading:16281914-RNA, Messenger,
pubmed-meshheading:16281914-Rats,
pubmed-meshheading:16281914-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16281914-S100 Proteins,
pubmed-meshheading:16281914-Subarachnoid Hemorrhage,
pubmed-meshheading:16281914-Vasospasm, Intracranial,
pubmed-meshheading:16281914-Vertebrobasilar Insufficiency
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pubmed:year |
2005
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pubmed:articleTitle |
Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta, -eta and -zeta) in a rat model of cerebral basilar artery vasospasm.
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pubmed:affiliation |
Department of Neurosurgery, Erasmus University Hospital, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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