Linked Life Data

16281887

Source:http://linkedlifedata.com/resource/pubmed/id/16281887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-11-11
pubmed:abstractText
During the design phase of a clinical trial, sample size estimates should take into account medical screening criteria, the 'healthy volunteer' effect, consequences of run-in phases, and secular trends in the event rate of interest. All of these have been shown to relate to subsequent event rates, and hence trial power to detect intervention effects. The Multiple Risk Factor Intervention Trial (MRFIT) used three successive screenings of 361 662 men to enroll 12 866; observed coronary heart disease (CHD) mortality after a mean of 6.9 years was substantially lower than projected during design. We explore factors which may have contributed to these mortality differences and whether they persisted throughout follow-up.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1740-7745
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
148-61
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Multiple-stage screening and mortality in the Multiple Risk Factor Intervention Trial.
pubmed:affiliation
Division of Biostatistics, School of Public Health, University of Minnesota, 420 Delaware Street SE, MMC 303, Minneapolis, MN 55455-0378, USA. lynn@biostat.umn.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural