| pubmed-article:16280364 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16280364 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:16280364 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:16280364 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16280364 | lifeskim:mentions | umls-concept:C2936272 | lld:lifeskim |
| pubmed-article:16280364 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:16280364 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:16280364 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16280364 | pubmed:dateCreated | 2006-1-25 | lld:pubmed |
| pubmed-article:16280364 | pubmed:abstractText | Although circadian transcription of Period2 (Per2) is fundamental for the generation of circadian rhythm, the molecular mechanism remains unclear. Here we report that cell-autonomous circadian transcription of Per2 is driven by two transcriptional elements, one for rhythm generation and the other for phase control. The former contains the E-box-like sequence (CACGTT) that is sufficient and indispensable to drive oscillation, and indeed circadian transcription factors site-specifically bind to it. Furthermore, the nature of this atypical E-box is different from that of the classical circadian E-box. The current feedback loop model is based mainly on Period1. Our results provide not only compelling evidence in support of this model but also an explanation for a general basic mechanism to produce various patterns in the phase and amplitude of cell-autonomous circadian gene expression. | lld:pubmed |
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| pubmed-article:16280364 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16280364 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16280364 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16280364 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16280364 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16280364 | pubmed:issn | 1059-1524 | lld:pubmed |
| pubmed-article:16280364 | pubmed:author | pubmed-author:AkashiMakotoM | lld:pubmed |
| pubmed-article:16280364 | pubmed:author | pubmed-author:TakumiToruT | lld:pubmed |
| pubmed-article:16280364 | pubmed:author | pubmed-author:MamineTakayos... | lld:pubmed |
| pubmed-article:16280364 | pubmed:author | pubmed-author:IchiseTomokoT | lld:pubmed |
| pubmed-article:16280364 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16280364 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:16280364 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16280364 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16280364 | pubmed:pagination | 555-65 | lld:pubmed |
| pubmed-article:16280364 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16280364 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16280364 | pubmed:articleTitle | Molecular mechanism of cell-autonomous circadian gene expression of Period2, a crucial regulator of the mammalian circadian clock. | lld:pubmed |
| pubmed-article:16280364 | pubmed:affiliation | Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan. | lld:pubmed |
| pubmed-article:16280364 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16280364 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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