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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-1-25
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pubmed:abstractText |
Although circadian transcription of Period2 (Per2) is fundamental for the generation of circadian rhythm, the molecular mechanism remains unclear. Here we report that cell-autonomous circadian transcription of Per2 is driven by two transcriptional elements, one for rhythm generation and the other for phase control. The former contains the E-box-like sequence (CACGTT) that is sufficient and indispensable to drive oscillation, and indeed circadian transcription factors site-specifically bind to it. Furthermore, the nature of this atypical E-box is different from that of the classical circadian E-box. The current feedback loop model is based mainly on Period1. Our results provide not only compelling evidence in support of this model but also an explanation for a general basic mechanism to produce various patterns in the phase and amplitude of cell-autonomous circadian gene expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16280364-10408444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16280364-10428031,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16280364-9988221
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1059-1524
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
555-65
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16280364-Animals,
pubmed-meshheading:16280364-Cell Cycle Proteins,
pubmed-meshheading:16280364-Circadian Rhythm,
pubmed-meshheading:16280364-E-Box Elements,
pubmed-meshheading:16280364-Gene Expression Regulation,
pubmed-meshheading:16280364-Genes, Reporter,
pubmed-meshheading:16280364-Mice,
pubmed-meshheading:16280364-Models, Biological,
pubmed-meshheading:16280364-NIH 3T3 Cells,
pubmed-meshheading:16280364-Nuclear Proteins,
pubmed-meshheading:16280364-Period Circadian Proteins,
pubmed-meshheading:16280364-RNA, Messenger,
pubmed-meshheading:16280364-Sequence Analysis, DNA,
pubmed-meshheading:16280364-Transcription, Genetic,
pubmed-meshheading:16280364-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Molecular mechanism of cell-autonomous circadian gene expression of Period2, a crucial regulator of the mammalian circadian clock.
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pubmed:affiliation |
Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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