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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
2005-11-10
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pubmed:abstractText |
Analogues of the natural product noscapine were synthesized and their potential as antitumor agents evaluated. The discovery of a novel regioselective O-demethylation facilitated the synthesis of the potent aniline 6, which arrests mammalian cells in the G2/M phase of the cell cycle at 0.1 microM and also affects tubulin polymerization. Aniline 6 is orally bioavailable and is 250-fold more potent than noscapine in reducing cell proliferation in rapidly dividing cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-2623
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pubmed:author |
pubmed-author:AndersonJames TJT,
pubmed-author:BennaniYoussef LYL,
pubmed-author:BoozerSherryS,
pubmed-author:BrundenKurt RKR,
pubmed-author:CrumrineChrisC,
pubmed-author:DanzigJoelJ,
pubmed-author:DentTomT,
pubmed-author:FagaLaurelL,
pubmed-author:HarringtonJohn JJJ,
pubmed-author:HodnickWilliam FWF,
pubmed-author:MurphySteven MSM,
pubmed-author:PawlowskiGaryG,
pubmed-author:PerryRobertR,
pubmed-author:RaberAmyA,
pubmed-author:RundlettStephen ESE,
pubmed-author:Stricker-KrongradAlainA,
pubmed-author:TingAnthony EAE,
pubmed-author:WangJianminJ
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7096-8
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pubmed:meshHeading |
pubmed-meshheading:16279766-Animals,
pubmed-meshheading:16279766-Antineoplastic Agents,
pubmed-meshheading:16279766-Biopolymers,
pubmed-meshheading:16279766-Cell Line,
pubmed-meshheading:16279766-Drug Screening Assays, Antitumor,
pubmed-meshheading:16279766-G2 Phase,
pubmed-meshheading:16279766-HeLa Cells,
pubmed-meshheading:16279766-Humans,
pubmed-meshheading:16279766-Mice,
pubmed-meshheading:16279766-Microtubules,
pubmed-meshheading:16279766-Noscapine,
pubmed-meshheading:16279766-Stereoisomerism,
pubmed-meshheading:16279766-Tubulin,
pubmed-meshheading:16279766-Tubulin Modulators
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pubmed:year |
2005
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pubmed:articleTitle |
Identification of novel and improved antimitotic agents derived from noscapine.
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pubmed:affiliation |
Athersys, Inc., 3201 Carnegie Avenue, Cleveland, Ohio 44115-2634, USA. janderson@athersys.com
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pubmed:publicationType |
Journal Article
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