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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-11-8
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pubmed:abstractText |
Major changes in drug clearance and metabolism are observed during infancy, in part based on ontogenic regulation of various metabolic pathways. Since paracetamol provides a good substrate to study UGT (1A6) activity, urinary metabolites of propacetamol were determined in neonates in whom propacetamol was repeatedly administered.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0803-5253
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1273-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16278989-Acetaminophen,
pubmed-meshheading:16278989-Age Factors,
pubmed-meshheading:16278989-Analgesics,
pubmed-meshheading:16278989-Body Weight,
pubmed-meshheading:16278989-Chromatography, High Pressure Liquid,
pubmed-meshheading:16278989-Gestational Age,
pubmed-meshheading:16278989-Humans,
pubmed-meshheading:16278989-Infant, Newborn,
pubmed-meshheading:16278989-Intensive Care Units, Neonatal,
pubmed-meshheading:16278989-Linear Models,
pubmed-meshheading:16278989-Metabolic Clearance Rate,
pubmed-meshheading:16278989-Multivariate Analysis,
pubmed-meshheading:16278989-Urination
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pubmed:year |
2005
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pubmed:articleTitle |
Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates.
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pubmed:affiliation |
Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital, Gasthuisberg, Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
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