| pubmed-article:16278864 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16278864 | lifeskim:mentions | umls-concept:C0003857 | lld:lifeskim |
| pubmed-article:16278864 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:16278864 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:16278864 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:16278864 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16278864 | pubmed:dateCreated | 2006-1-2 | lld:pubmed |
| pubmed-article:16278864 | pubmed:abstractText | We recently reported that the GG genotype of the interleukin-6 (IL-6)-174G>C promoter polymorphism is associated with clinical presentation of intracranial hemorrhage in brain arteriovenous malformation (AVM) patients. In this study, we investigated whether tissue IL-6 expression was associated with IL-6-174G>C genotype, and whether IL-6 was linked to downstream targets involved in angiogenesis and vascular instability. Our results showed that the highest IL-6 protein levels in brain AVM tissue were associated with IL-6-174GG genotype (GG: 57.7 +/- 20.2; GC: 35.6 +/- 26.6; CC: 13.9 +/- 10.2pg/mg; p = 0.001). IL-6 protein levels were increased in AVM tissue from patients with hemorrhagic presentation compared with patients without hemorrhage (55 +/- 22 vs 40 +/- 27pg/mg; p = 0.038). IL-6 messenger RNA expression strongly correlated with messenger RNA levels of IL-1beta, tumor necrosis factor-alpha, IL-8, matrix metalloproteinase-3 (MMP-3), MMP-9, and MMP-12. We further investigated the plausibility of IL-6 being an upstream cytokine responsible for initiating the angiogenic cascade by cell culture and animal experiments. IL-6 induced MMP-3 and MMP-9 expression and activity in mouse brain and increased proliferation and migration of cerebral endothelial cells. Together, our results suggest that the IL-6 genotype associated with intracranial hemorrhage modulates IL-6 expression in brain AVM tissue, which is consistent with the hypothesis that inflammatory processes induce angiogenic activity possibly contributory to brain AVM intracranial hemorrhage. | lld:pubmed |
| pubmed-article:16278864 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16278864 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16278864 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16278864 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16278864 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16278864 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16278864 | pubmed:issn | 0364-5134 | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:TostiEE | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:YoungWilliam... | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:LawtonMichael... | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:KwokPui-YanPY | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:ChenYongmeiY | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:YangGuo-YuanG... | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:YaoJianhua... | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:PawlikowskaLu... | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:AchrolAchal... | lld:pubmed |
| pubmed-article:16278864 | pubmed:author | pubmed-author:ShenFanxiaF | lld:pubmed |
| pubmed-article:16278864 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16278864 | pubmed:volume | 59 | lld:pubmed |
| pubmed-article:16278864 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16278864 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16278864 | pubmed:pagination | 72-80 | lld:pubmed |
| pubmed-article:16278864 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:16278864 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16278864 | pubmed:articleTitle | Interleukin-6 involvement in brain arteriovenous malformations. | lld:pubmed |
| pubmed-article:16278864 | pubmed:affiliation | Center for Cerebrovascular Research, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA, USA. | lld:pubmed |
| pubmed-article:16278864 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16278864 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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