Source:http://linkedlifedata.com/resource/pubmed/id/16278864
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-1-2
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pubmed:abstractText |
We recently reported that the GG genotype of the interleukin-6 (IL-6)-174G>C promoter polymorphism is associated with clinical presentation of intracranial hemorrhage in brain arteriovenous malformation (AVM) patients. In this study, we investigated whether tissue IL-6 expression was associated with IL-6-174G>C genotype, and whether IL-6 was linked to downstream targets involved in angiogenesis and vascular instability. Our results showed that the highest IL-6 protein levels in brain AVM tissue were associated with IL-6-174GG genotype (GG: 57.7 +/- 20.2; GC: 35.6 +/- 26.6; CC: 13.9 +/- 10.2pg/mg; p = 0.001). IL-6 protein levels were increased in AVM tissue from patients with hemorrhagic presentation compared with patients without hemorrhage (55 +/- 22 vs 40 +/- 27pg/mg; p = 0.038). IL-6 messenger RNA expression strongly correlated with messenger RNA levels of IL-1beta, tumor necrosis factor-alpha, IL-8, matrix metalloproteinase-3 (MMP-3), MMP-9, and MMP-12. We further investigated the plausibility of IL-6 being an upstream cytokine responsible for initiating the angiogenic cascade by cell culture and animal experiments. IL-6 induced MMP-3 and MMP-9 expression and activity in mouse brain and increased proliferation and migration of cerebral endothelial cells. Together, our results suggest that the IL-6 genotype associated with intracranial hemorrhage modulates IL-6 expression in brain AVM tissue, which is consistent with the hypothesis that inflammatory processes induce angiogenic activity possibly contributory to brain AVM intracranial hemorrhage.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0364-5134
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
72-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16278864-Adult,
pubmed-meshheading:16278864-Aged,
pubmed-meshheading:16278864-Animals,
pubmed-meshheading:16278864-Brain,
pubmed-meshheading:16278864-Cells, Cultured,
pubmed-meshheading:16278864-Endothelial Cells,
pubmed-meshheading:16278864-Genotype,
pubmed-meshheading:16278864-Humans,
pubmed-meshheading:16278864-Interleukin-6,
pubmed-meshheading:16278864-Intracranial Arteriovenous Malformations,
pubmed-meshheading:16278864-Matrix Metalloproteinases,
pubmed-meshheading:16278864-Mice,
pubmed-meshheading:16278864-Middle Aged,
pubmed-meshheading:16278864-Polymorphism, Genetic,
pubmed-meshheading:16278864-Promoter Regions, Genetic,
pubmed-meshheading:16278864-RNA, Messenger,
pubmed-meshheading:16278864-Statistics as Topic
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pubmed:year |
2006
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pubmed:articleTitle |
Interleukin-6 involvement in brain arteriovenous malformations.
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pubmed:affiliation |
Center for Cerebrovascular Research, University of California at San Francisco, 1001 Potrero Avenue, San Francisco, CA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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