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pubmed:abstractText |
Triblock copolymeric nanoreactors are introduced as an alternative for liposomes as encapsulating carrier for prodrug activating enzymes. Inosine-adenosine-guanosine preferring nucleoside hydrolase of Trypanosoma vivax, a potential prodrug activating enzyme, was encapsulated in nanometer-sized vesicles constructed of poly(2-methyloxazoline)-block-poly(dimethylsiloxane)-block-(2-methyloxazoline) triblock copolymers. The nanoreactor is functionalized by incorporation of bacterial porins, OmpF or Tsx, in the reactor wall. Efficient cleavage of three natural substrates and one prodrug, 2-fluoroadenosine, by the nanoreactors was demonstrated.
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pubmed:affiliation |
Department of Molecular and Cellular Interactions, Vrije Universiteit Brussel (VUB) and Vlaams Interuniversitair Instituut voor Biotechnology (VIB6), Pleinlaan 2, 1050 Brussels, Belgium. aranquin@vub.ac.be
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