Source:http://linkedlifedata.com/resource/pubmed/id/16277168
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2005-11-9
|
| pubmed:abstractText |
Elevated liver enzymes can be seen relatively frequently in patients with Turner syndrome (TS), while the pathogenesis of this remains unclear. Our epidemiological and prospective study aimed to investigate: a) the natural 2-yr course of liver disease in a selected cohort of young patients with TS, who had been preliminarily recruited on the basis of persistently elevated liver enzymes; b) the role of prolonged hormonal therapies in the etiology of liver dysfunction. From an overall population of 214 TS patients younger than 20 yr, only 19 (8.9%) were recruited, according to the following inclusion criteria: increased serum concentrations of one or more liver enzymes, exceeding the uppermost limit of the respective normal ranges, and persistence of these liver alterations for 6 months after the preliminary assessment. On the basis of the results of this prospective study, we can conclude that: a) the prevalence of liver abnormalities in girls and adolescents with TS is much lower and more strictly related to hormonal therapies than in TS adults; b) both autoimmunity and obesity are not frequently involved in the etiology of TS liver dysfunction; c) liver damage is either mild or moderate and its severity is not conditioned by karyotype; d) its course may be self-limiting; e) its natural history may be characterized in some cases by a slight deterioration of intrahepatic cholestasis, with no negative repercussions on liver synthetic function.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Human Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Glutamyltransferase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0391-4097
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
720-6
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| pubmed:meshHeading |
pubmed-meshheading:16277168-Adolescent,
pubmed-meshheading:16277168-Adult,
pubmed-meshheading:16277168-Alanine Transaminase,
pubmed-meshheading:16277168-Aspartate Aminotransferases,
pubmed-meshheading:16277168-Body Mass Index,
pubmed-meshheading:16277168-Child,
pubmed-meshheading:16277168-Child, Preschool,
pubmed-meshheading:16277168-Chromosome Aberrations,
pubmed-meshheading:16277168-Cohort Studies,
pubmed-meshheading:16277168-Ethinyl Estradiol,
pubmed-meshheading:16277168-Female,
pubmed-meshheading:16277168-Human Growth Hormone,
pubmed-meshheading:16277168-Humans,
pubmed-meshheading:16277168-Liver Diseases,
pubmed-meshheading:16277168-Longitudinal Studies,
pubmed-meshheading:16277168-Prospective Studies,
pubmed-meshheading:16277168-Turner Syndrome,
pubmed-meshheading:16277168-gamma-Glutamyltransferase
|
| pubmed:year |
2005
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| pubmed:articleTitle |
Increased liver enzymes and hormonal therapies in girls and adolescents with Turner syndrome.
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| pubmed:affiliation |
Department of Pediatrics, University of Messina, Messina, Italy. wasniewska@yahoo.it
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| pubmed:publicationType |
Journal Article
|