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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2005-11-15
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pubmed:abstractText |
AMP-activated protein kinase (AMPK) regulatory gamma2 subunit (PRKAG2) mutations cause a human cardiomyopathy with cardiac hypertrophy, preexcitation, and glycogen deposition. PRKAG2 cardiomyopathy is recapitulated in transgenic mice overexpressing mutant PRKAG2 N488I in the heart (TGgamma2N488I). AMPK is a heterotrimeric kinase consisting of 1 catalytic (alpha) and 2 regulatory (beta and gamma) subunits. Two alpha-subunit isoforms, alpha1 and alpha2, are expressed in the heart; however, the contribution of AMPK utilization of these subunits to PRKAG2 cardiomyopathy is unknown. Mice overexpressing a dominant-negative alpha2 subunit of AMPK (TGalpha2DN) provide a tool for selectively inhibiting alpha2, but not alpha1, subunit-associated AMPK activity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AhmadFerhaanF,
pubmed-author:AradMichaelM,
pubmed-author:BaliDeekshaD,
pubmed-author:BerulCharles ICI,
pubmed-author:BrancoDorothyD,
pubmed-author:GoodyearLaurie JLJ,
pubmed-author:HeHuameiH,
pubmed-author:IngwallJoanne SJS,
pubmed-author:MusiNicolasN,
pubmed-author:NazSS,
pubmed-author:Perez-AtaydeAntonio RAR,
pubmed-author:SeidmanChristine ECE,
pubmed-author:SeidmanJ GJG,
pubmed-author:StapletonDavidD,
pubmed-author:WolfCordulaC,
pubmed-author:XingYanqiuY
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3140-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16275868-AMP-Activated Protein Kinases,
pubmed-meshheading:16275868-Amino Acid Substitution,
pubmed-meshheading:16275868-Animals,
pubmed-meshheading:16275868-Cardiomyopathies,
pubmed-meshheading:16275868-Disease Models, Animal,
pubmed-meshheading:16275868-Echocardiography,
pubmed-meshheading:16275868-Exercise Test,
pubmed-meshheading:16275868-Humans,
pubmed-meshheading:16275868-Mice,
pubmed-meshheading:16275868-Mice, Transgenic,
pubmed-meshheading:16275868-Multienzyme Complexes,
pubmed-meshheading:16275868-Mutation, Missense,
pubmed-meshheading:16275868-Protein Kinases,
pubmed-meshheading:16275868-Protein Subunits,
pubmed-meshheading:16275868-Protein-Serine-Threonine Kinases
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pubmed:year |
2005
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pubmed:articleTitle |
Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy.
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pubmed:affiliation |
Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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