Source:http://linkedlifedata.com/resource/pubmed/id/16275078
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2005-11-25
|
| pubmed:abstractText |
An efficient method for the synthesis of 7-deazaneplanocin A (2) has been accomplished by the condensation of cyclopentenol 3 with 6-chloro-7-deazapurine followed by subsequent functional group manipulations. The synthesized 7-deazaneplanocin A (2) exhibited potent antiviral activity against cowpox and vaccinia viruses without cytotoxicity in HFF cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
285-7
|
| pubmed:dateRevised |
2009-1-28
|
| pubmed:meshHeading |
pubmed-meshheading:16275078-Adenosine,
pubmed-meshheading:16275078-Antiviral Agents,
pubmed-meshheading:16275078-Drug Evaluation, Preclinical,
pubmed-meshheading:16275078-Microbial Sensitivity Tests,
pubmed-meshheading:16275078-Molecular Conformation,
pubmed-meshheading:16275078-Orthopoxvirus,
pubmed-meshheading:16275078-Structure-Activity Relationship
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus).
|
| pubmed:affiliation |
University of Georgia College of Pharmacy, Athens, GA 30602, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|